Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 797538..798195 Replicon chromosome
Accession NZ_CP118906
Organism Klebsiella pneumoniae strain T-hvKP

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag PXG78_RS03960 Protein ID WP_002916310.1
Coordinates 797785..798195 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag PXG78_RS03955 Protein ID WP_002916312.1
Coordinates 797538..797804 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXG78_RS03930 (792746) 792746..794179 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
PXG78_RS03935 (794298) 794298..795026 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
PXG78_RS03940 (795076) 795076..795387 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
PXG78_RS03945 (795551) 795551..796210 + 660 WP_002916317.1 hemolysin III family protein -
PXG78_RS03950 (796309) 796309..797292 - 984 WP_014906951.1 tRNA-modifying protein YgfZ -
PXG78_RS03955 (797538) 797538..797804 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
PXG78_RS03960 (797785) 797785..798195 + 411 WP_002916310.1 protein YgfX Toxin
PXG78_RS03965 (798202) 798202..798723 - 522 WP_002916308.1 flavodoxin FldB -
PXG78_RS03970 (798824) 798824..799720 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
PXG78_RS03975 (799743) 799743..800456 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PXG78_RS03980 (800462) 800462..802195 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T273550 WP_002916310.1 NZ_CP118906:797785-798195 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT273550 WP_002916312.1 NZ_CP118906:797538-797804 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References