Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 78245..79155 | Replicon | plasmid pCRKP-1 |
| Accession | NZ_CP118902 | ||
| Organism | Klebsiella pneumoniae strain CRKP | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | R4YBC5 |
| Locus tag | PXG74_RS26340 | Protein ID | WP_004144067.1 |
| Coordinates | 78245..78715 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6A8PHD0 |
| Locus tag | PXG74_RS26345 | Protein ID | WP_023287184.1 |
| Coordinates | 78712..79155 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PXG74_RS26320 (PXG74_26320) | 74471..75439 | - | 969 | WP_074423483.1 | IS5 family transposase | - |
| PXG74_RS26325 (PXG74_26325) | 75744..76004 | + | 261 | WP_017901409.1 | hypothetical protein | - |
| PXG74_RS26330 (PXG74_26330) | 76193..77161 | - | 969 | WP_023279773.1 | IS5 family transposase | - |
| PXG74_RS26335 (PXG74_26335) | 77163..78158 | - | 996 | WP_077254794.1 | IS5 family transposase | - |
| PXG74_RS26340 (PXG74_26340) | 78245..78715 | - | 471 | WP_004144067.1 | RES family NAD+ phosphorylase | Toxin |
| PXG74_RS26345 (PXG74_26345) | 78712..79155 | - | 444 | WP_023287184.1 | DUF2384 domain-containing protein | Antitoxin |
| PXG74_RS26350 (PXG74_26350) | 79256..80398 | - | 1143 | Protein_85 | translesion error-prone DNA polymerase V subunit UmuC | - |
| PXG74_RS26355 (PXG74_26355) | 80451..81797 | - | 1347 | WP_225517490.1 | ThiF family adenylyltransferase | - |
| PXG74_RS26360 (PXG74_26360) | 81993..82961 | - | 969 | WP_000654811.1 | IS5 family transposase | - |
| PXG74_RS26365 (PXG74_26365) | 82990..83739 | - | 750 | Protein_88 | IS5 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | tet(B) / ARR-3 / dfrA27 / aadA16 / qacE / sul1 / qnrB4 / blaDHA-1 | pla | 1..262673 | 262673 | |
| - | inside | IScluster/Tn | - | - | 74471..85883 | 11412 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17573.83 Da Isoelectric Point: 4.5152
>T273546 WP_004144067.1 NZ_CP118902:c78715-78245 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16522.84 Da Isoelectric Point: 10.3013
>AT273546 WP_023287184.1 NZ_CP118902:c79155-78712 [Klebsiella pneumoniae]
MKTFSLSSSPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSSPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A384IED8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6A8PHD0 |