Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4789373..4789889 Replicon chromosome
Accession NZ_CP118901
Organism Klebsiella pneumoniae strain CRKP

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag PXG74_RS23290 Protein ID WP_004178374.1
Coordinates 4789373..4789657 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag PXG74_RS23295 Protein ID WP_002886901.1
Coordinates 4789647..4789889 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXG74_RS23265 (4784769) 4784769..4785032 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
PXG74_RS23270 (4785162) 4785162..4785335 + 174 WP_032103426.1 hypothetical protein -
PXG74_RS23275 (4785338) 4785338..4786081 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
PXG74_RS23280 (4786438) 4786438..4788576 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
PXG74_RS23285 (4788905) 4788905..4789369 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PXG74_RS23290 (4789373) 4789373..4789657 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PXG74_RS23295 (4789647) 4789647..4789889 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PXG74_RS23300 (4789967) 4789967..4791877 - 1911 WP_015959311.1 PRD domain-containing protein -
PXG74_RS23305 (4791900) 4791900..4793054 - 1155 WP_004178372.1 lactonase family protein -
PXG74_RS23310 (4793121) 4793121..4793861 - 741 WP_015959310.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T273541 WP_004178374.1 NZ_CP118901:c4789657-4789373 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT273541 WP_002886901.1 NZ_CP118901:c4789889-4789647 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References