Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2651949..2653537 Replicon chromosome
Accession NZ_CP118901
Organism Klebsiella pneumoniae strain CRKP

Toxin (Protein)


Gene name hipA Uniprot ID A6T928
Locus tag PXG74_RS12935 Protein ID WP_004176197.1
Coordinates 2651949..2653271 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag PXG74_RS12940 Protein ID WP_002904790.1
Coordinates 2653271..2653537 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXG74_RS12920 (2647005) 2647005..2649506 + 2502 WP_032412215.1 fimbria/pilus outer membrane usher protein -
PXG74_RS12925 (2649494) 2649494..2650498 + 1005 WP_032434525.1 fimbrial protein -
PXG74_RS12930 (2650640) 2650640..2651932 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
PXG74_RS12935 (2651949) 2651949..2653271 - 1323 WP_004176197.1 type II toxin-antitoxin system HipA family toxin Toxin
PXG74_RS12940 (2653271) 2653271..2653537 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PXG74_RS12945 (2653803) 2653803..2654129 - 327 WP_002904788.1 hydroxyisourate hydrolase -
PXG74_RS12950 (2654126) 2654126..2654626 - 501 WP_032434523.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
PXG74_RS12955 (2654604) 2654604..2655983 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
PXG74_RS12960 (2656329) 2656329..2657483 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
PXG74_RS12965 (2657464) 2657464..2658387 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49111.41 Da        Isoelectric Point: 7.5357

>T273538 WP_004176197.1 NZ_CP118901:c2653271-2651949 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT273538 WP_002904790.1 NZ_CP118901:c2653537-2653271 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6T928

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References