Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3467770..3468404 Replicon chromosome
Accession NZ_CP118892
Organism Acinetobacter sp. TAC-1

Toxin (Protein)


Gene name hicA Uniprot ID A0A072D989
Locus tag PYV58_RS16120 Protein ID WP_034614022.1
Coordinates 3468222..3468404 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A072CWY9
Locus tag PYV58_RS16115 Protein ID WP_034614020.1
Coordinates 3467770..3468180 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYV58_RS16105 (PYV58_16105) 3465169..3465897 - 729 WP_034614018.1 fimbria/pilus periplasmic chaperone -
PYV58_RS16110 (PYV58_16110) 3465977..3466510 - 534 WP_004819818.1 fimbrial protein -
PYV58_RS16115 (PYV58_16115) 3467770..3468180 - 411 WP_034614020.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PYV58_RS16120 (PYV58_16120) 3468222..3468404 - 183 WP_034614022.1 type II toxin-antitoxin system HicA family toxin Toxin
PYV58_RS16125 (PYV58_16125) 3468645..3468872 - 228 WP_034614024.1 DUF2188 domain-containing protein -
PYV58_RS16130 (PYV58_16130) 3472044..3472658 - 615 WP_034617979.1 type I-F CRISPR-associated endoribonuclease Cas6/Csy4 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6771.95 Da        Isoelectric Point: 10.1008

>T273526 WP_034614022.1 NZ_CP118892:c3468404-3468222 [Acinetobacter sp. TAC-1]
MKSLELIKMIEADGWYEVRVKGSHHHFKHPTKEGLVTVPHPKKDLPTGTVKSILKQAGLE

Download         Length: 183 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14885.87 Da        Isoelectric Point: 4.3885

>AT273526 WP_034614020.1 NZ_CP118892:c3468180-3467770 [Acinetobacter sp. TAC-1]
MLYPIAVEKGSNDEAYGVIVPDIQGCFSAGDTFEEALSNAKEAIADHLEILAEDGKNIPLASEVSKFLNDEEFKGFIWAV
VEVDVNRYLGKAEKINVTLPSRLIYLIDDKVGKDKQYKSRSAFLAAGAEKILQASS

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A072D989

Antitoxin

Source ID Structure
AlphaFold DB A0A072CWY9

References