Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 68257..68834 Replicon plasmid p12100-NDM
Accession NZ_CP118864
Organism Providencia rettgeri strain 12100

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NTP66_RS20110 Protein ID WP_048607647.1
Coordinates 68502..68834 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID U5N340
Locus tag NTP66_RS20105 Protein ID WP_023159984.1
Coordinates 68257..68502 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTP66_RS20070 63959..64303 + 345 WP_023159966.1 single-stranded DNA-binding protein -
NTP66_RS20075 64296..64718 + 423 WP_147675444.1 hypothetical protein -
NTP66_RS20080 64728..65120 + 393 WP_147675443.1 hypothetical protein -
NTP66_RS20085 65157..66227 + 1071 WP_172688831.1 hypothetical protein -
NTP66_RS20090 66584..66952 + 369 WP_172688830.1 hypothetical protein -
NTP66_RS20095 67050..67277 - 228 WP_048607652.1 plasmid partition protein ParG -
NTP66_RS20100 67368..67991 - 624 WP_147675501.1 ParA family protein -
NTP66_RS20105 68257..68502 + 246 WP_023159984.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NTP66_RS20110 68502..68834 + 333 WP_048607647.1 endoribonuclease MazF Toxin
NTP66_RS20115 68869..69249 + 381 WP_147675500.1 hypothetical protein -
NTP66_RS20120 69336..69479 - 144 WP_071547955.1 Hok/Gef family protein -
NTP66_RS20125 69844..70641 - 798 WP_147675499.1 hypothetical protein -
NTP66_RS20130 71044..71997 + 954 WP_048821757.1 site-specific integrase -
NTP66_RS20135 72013..72828 + 816 WP_071547989.1 DUF4365 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid rmtB2 / blaNDM-1 - 1..118246 118246


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-107)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12081.82 Da        Isoelectric Point: 7.1057

>T273521 WP_048607647.1 NZ_CP118864:68502-68834 [Providencia rettgeri]
MVSRYVPDSGDLIWIDFDPVEGHEQGGHRPAVVLSPFAYNNKVGLLLCVPCTTKGKGYPFECELSNERDSYALADQVTSV
DWRARKVTKKGKVEASELAEIKAKAKALIG

Download         Length: 333 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8786.20 Da        Isoelectric Point: 5.0351

>AT273521 WP_023159984.1 NZ_CP118864:68257-68502 [Providencia rettgeri]
MAQVTVKKWGNSPSVRLPVAIMQKAALSVDDTVEIAVEEGRIIITPVKAVEYSLDNLLAGITPENIHEKVDFGARTGKEL
I

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A857E7M9

References