Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 29017..29543 Replicon plasmid p12100-NDM
Accession NZ_CP118864
Organism Providencia rettgeri strain 12100

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag NTP66_RS19870 Protein ID WP_000323025.1
Coordinates 29256..29543 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q5J3S4
Locus tag NTP66_RS19865 Protein ID WP_000534857.1
Coordinates 29017..29256 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTP66_RS19840 24715..25215 + 501 Protein_24 glutathione binding-like protein -
NTP66_RS19845 25212..26180 + 969 WP_048266650.1 magnesium and cobalt transport protein CorA -
NTP66_RS19850 26508..28001 + 1494 WP_048266652.1 IS91 family transposase -
NTP66_RS19855 28113..28817 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
NTP66_RS19860 28882..28992 - 111 Protein_28 protein YdfV -
NTP66_RS19865 29017..29256 + 240 WP_000534857.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
NTP66_RS19870 29256..29543 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
NTP66_RS19875 29826..30050 + 225 Protein_31 hypothetical protein -
NTP66_RS19880 30227..31207 + 981 WP_022652288.1 IS5-like element IS5 family transposase -
NTP66_RS19885 31339..31683 + 345 Protein_33 endonuclease -
NTP66_RS19890 31902..32105 - 204 WP_071548929.1 type II toxin-antitoxin system RelE/ParE family toxin -
NTP66_RS19895 32283..32633 + 351 Protein_35 pentapeptide MXKDX repeat protein -
NTP66_RS19900 32847..33140 - 294 WP_071548928.1 type II toxin-antitoxin system RelE/ParE family toxin -
NTP66_RS19905 33133..33375 - 243 WP_071548927.1 type II toxin-antitoxin system ParD family antitoxin -
NTP66_RS19910 33570..34202 + 633 WP_071548926.1 recombinase family protein -
NTP66_RS19915 34232..34504 + 273 WP_071548925.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid rmtB2 / blaNDM-1 - 1..118246 118246
- flank IS/Tn - - 33570..34202 632


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T273520 WP_000323025.1 NZ_CP118864:29256-29543 [Providencia rettgeri]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9085.55 Da        Isoelectric Point: 4.6820

>AT273520 WP_000534857.1 NZ_CP118864:29017-29256 [Providencia rettgeri]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRKPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A6C0NE60

References