Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4340892..4342468 Replicon chromosome
Accession NZ_CP118863
Organism Providencia rettgeri strain 12100

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NTP66_RS19685 Protein ID WP_140172675.1
Coordinates 4340892..4342211 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NTP66_RS19690 Protein ID WP_140172676.1
Coordinates 4342211..4342468 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTP66_RS19675 4336829..4339876 - 3048 WP_282550878.1 formate dehydrogenase-N subunit alpha -
NTP66_RS19680 4340051..4340881 + 831 WP_036959175.1 formate dehydrogenase accessory sulfurtransferase FdhD -
NTP66_RS19685 4340892..4342211 - 1320 WP_140172675.1 type II toxin-antitoxin system HipA family toxin Toxin
NTP66_RS19690 4342211..4342468 - 258 WP_140172676.1 helix-turn-helix domain-containing protein Antitoxin
NTP66_RS19695 4342791..4344155 - 1365 WP_004906223.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
NTP66_RS19700 4344257..4345906 - 1650 WP_004906225.1 membrane protein insertase YidC -
NTP66_RS19705 4345909..4346169 - 261 WP_283558161.1 membrane protein insertion efficiency factor YidD -
NTP66_RS19710 4346133..4346492 - 360 WP_004906229.1 ribonuclease P protein component -
NTP66_RS19715 4346514..4346657 - 144 WP_004906236.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 50013.00 Da        Isoelectric Point: 6.5676

>T273519 WP_140172675.1 NZ_CP118863:c4342211-4340892 [Providencia rettgeri]
MATLHVYMNGYLVGDLIRSSTGAHQFTYNSHWLETSGARPISLSMPLRHQEYRGDEVYNFFDNLLPDNIEIRNRIVSRYQ
ADSNQPFDLLSKIGQDSVGALQLILDGQRVSNIRKIEYKPLSNKQLEKILTGYKANAPLGMIEDEDDFRISLAGAQEKTA
LLYLDGHWCLPQNATPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKEFGLDVPYSFILNVGEIKALAVERFDRK
YSSDSSWIMRLPQEDFCQTLNISPARKYQNHGGPGISEIMNYLLGSINAEKDRYQFMKSQVLFWLLAATDGHAKNFSLFI
EPEGRYQLTPFYDILSMYPSYGGRGINPRDAKLAMGLKGTRGMKYNIEQIFPRHFFSTAKAVGFDRAEMEKILIEFGEQM
ESVIKKVREQLPTDFPEHIADSILSGLHHKAARLNKGWD

Download         Length: 1320 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9658.94 Da        Isoelectric Point: 9.6898

>AT273519 WP_140172676.1 NZ_CP118863:c4342468-4342211 [Providencia rettgeri]
MKVTNTRQLSAYMKDVREMKKLSQSKVASKVGIRQDTVSSFELSPDSTKLETFFKILSALNLELDIKPRNESGSSNSDSG
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References