Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 4213961..4214544 Replicon chromosome
Accession NZ_CP118863
Organism Providencia rettgeri strain 12100

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag NTP66_RS19050 Protein ID WP_140172875.1
Coordinates 4214242..4214544 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NTP66_RS19045 Protein ID WP_004265229.1
Coordinates 4213961..4214245 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTP66_RS19020 4209121..4210098 - 978 WP_004265237.1 6-phosphofructokinase -
NTP66_RS19025 4210505..4211449 - 945 WP_102140623.1 phosphatidate cytidylyltransferase -
NTP66_RS19030 4211446..4212087 - 642 WP_140172874.1 lysophospholipid acyltransferase family protein -
NTP66_RS19035 4212325..4213077 - 753 WP_004907010.1 M48 family metallopeptidase -
NTP66_RS19040 4213297..4213878 - 582 WP_094961882.1 HutD family protein -
NTP66_RS19045 4213961..4214245 - 285 WP_004265229.1 putative addiction module antidote protein Antitoxin
NTP66_RS19050 4214242..4214544 - 303 WP_140172875.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NTP66_RS19055 4214852..4215622 + 771 WP_094961881.1 hypothetical protein -
NTP66_RS19060 4215652..4215870 - 219 WP_094961880.1 ogr/Delta-like zinc finger family protein -
NTP66_RS19065 4215942..4217039 - 1098 WP_125893516.1 phage late control D family protein -
NTP66_RS19070 4217036..4217482 - 447 WP_102140831.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4213961..4247628 33667


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11463.39 Da        Isoelectric Point: 9.8470

>T273518 WP_140172875.1 NZ_CP118863:c4214544-4214242 [Providencia rettgeri]
MITVLTTECFDSWIKNLRDIRAKTKILMRIRWLKNGNYGDVQPIGDGFSELRVHEGQGYRVYLKQKNNVIVILLCGGTKA
TQQKDIHKAKLLFGEVEGEL

Download         Length: 303 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10454.13 Da        Isoelectric Point: 4.5983

>AT273518 WP_004265229.1 NZ_CP118863:c4214245-4213961 [Providencia rettgeri]
MNTKLKEFDIAEYLNSEEEIQMYLNEILEEGDPSLVLAALGDIAKARNMSQLAKEVGMSREGLYKALSGQGNPTFMTIIK
IVNSLGLKLQFKSI

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References