Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 3958774..3959359 Replicon chromosome
Accession NZ_CP118863
Organism Providencia rettgeri strain 12100

Toxin (Protein)


Gene name relE Uniprot ID D4C3N9
Locus tag NTP66_RS17770 Protein ID WP_004905874.1
Coordinates 3958774..3959091 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4C3P0
Locus tag NTP66_RS17775 Protein ID WP_004905876.1
Coordinates 3959072..3959359 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTP66_RS17740 3954477..3954728 - 252 WP_140171816.1 DUF1471 domain-containing protein -
NTP66_RS17745 3954999..3955337 + 339 WP_140171817.1 GIY-YIG nuclease family protein -
NTP66_RS17750 3955310..3955813 - 504 WP_112308100.1 N-acetyltransferase -
NTP66_RS17755 3955807..3956331 - 525 WP_140171818.1 SCP2 domain-containing protein -
NTP66_RS17760 3956846..3957841 + 996 WP_140171819.1 peptidase U32 family protein -
NTP66_RS17765 3957859..3958734 + 876 WP_140171820.1 U32 family peptidase -
NTP66_RS17770 3958774..3959091 - 318 WP_004905874.1 type II toxin-antitoxin system YafQ family toxin Toxin
NTP66_RS17775 3959072..3959359 - 288 WP_004905876.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NTP66_RS17780 3959490..3960644 - 1155 WP_140171821.1 ABC transporter permease -
NTP66_RS17785 3960644..3961789 - 1146 WP_004905879.1 ABC transporter permease -
NTP66_RS17790 3961801..3962772 - 972 WP_140171822.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(14-105)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12205.96 Da        Isoelectric Point: 9.7799

>T273517 WP_004905874.1 NZ_CP118863:c3959091-3958774 [Providencia rettgeri]
MTQKPSNKRAKQPRQVAYTPTFKKSWERYNRAGRRDMNAAVLVMEILFSQKIIPKEYLDHELEGHEWQGARELHIGGDFL
LVYRLSDKGNLITFVDIGSHSELFG

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10763.44 Da        Isoelectric Point: 5.8809

>AT273517 WP_004905876.1 NZ_CP118863:c3959359-3959072 [Providencia rettgeri]
MSTLLKTTDVRSRIDEQLKAEATSVLQDCGLTISAAIRLFLEQVVQEQRVPFEIKRKQPSLKTTLALKEAKAIEQHYDSI
NEMMVELSKVDSEAK

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4C3N9

Antitoxin

Source ID Structure
AlphaFold DB A0A345M0A6

References