Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1694229..1694877 Replicon chromosome
Accession NZ_CP118863
Organism Providencia rettgeri strain 12100

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NTP66_RS07295 Protein ID WP_094961724.1
Coordinates 1694692..1694877 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NTP66_RS07290 Protein ID WP_094961723.1
Coordinates 1694229..1694642 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTP66_RS07265 1689544..1690680 - 1137 WP_180359534.1 M4 family metallopeptidase -
NTP66_RS07270 1690839..1691756 - 918 WP_140172324.1 oxygen-dependent coproporphyrinogen oxidase -
NTP66_RS07275 1691893..1692324 + 432 WP_109911483.1 GNAT family acetyltransferase -
NTP66_RS07280 1692416..1693021 + 606 WP_140172325.1 RpoE-regulated lipoprotein -
NTP66_RS07285 1693264..1694163 + 900 WP_094961722.1 Dyp-type peroxidase -
NTP66_RS07290 1694229..1694642 - 414 WP_094961723.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NTP66_RS07295 1694692..1694877 - 186 WP_094961724.1 type II toxin-antitoxin system HicA family toxin Toxin
NTP66_RS07300 1695200..1696222 + 1023 WP_140172326.1 sulfate ABC transporter substrate-binding protein -
NTP66_RS07305 1696222..1697052 + 831 WP_004264883.1 sulfate/thiosulfate ABC transporter permease CysT -
NTP66_RS07310 1697052..1697912 + 861 WP_200129238.1 sulfate/thiosulfate ABC transporter permease CysW -
NTP66_RS07315 1697915..1699003 + 1089 WP_094961726.1 sulfate/thiosulfate ABC transporter ATP-binding protein CysA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6992.20 Da        Isoelectric Point: 11.0146

>T273514 WP_094961724.1 NZ_CP118863:c1694877-1694692 [Providencia rettgeri]
VQSSELINILQKNGWKLERIKGSHHQFSHPHFSIVITVPHPQKDLKIGTLNHILKAAKLKH

Download         Length: 186 bp

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15362.31 Da        Isoelectric Point: 4.6719

>AT273514 WP_094961723.1 NZ_CP118863:c1694642-1694229 [Providencia rettgeri]
MLYTAFIEIDNDGSASGWFPDIEGCTFAGSNIEEAYAEAKSAIDAHFELLSEKGFEIPLSKSQQTLLNPIQPEYAHGIWL
FVDVDMDKYDGRTERINITLPHRLLHRIDALVKVNPEYGSRSGFIAAAARKELKKTD

Download         Length: 414 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References