Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 865226..865872 Replicon chromosome
Accession NZ_CP118863
Organism Providencia rettgeri strain 12100

Toxin (Protein)


Gene name Hha Uniprot ID B6XA97
Locus tag NTP66_RS03680 Protein ID WP_004905417.1
Coordinates 865226..865429 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D4C184
Locus tag NTP66_RS03685 Protein ID WP_004905413.1
Coordinates 865504..865872 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTP66_RS03655 861301..861639 + 339 WP_004905421.1 P-II family nitrogen regulator -
NTP66_RS03660 861689..862936 + 1248 WP_227528974.1 ammonium transporter AmtB -
NTP66_RS03665 863075..863944 - 870 WP_109911901.1 acyl-CoA thioesterase II -
NTP66_RS03670 864184..864642 + 459 WP_140172116.1 YbaY family lipoprotein -
NTP66_RS03680 865226..865429 - 204 WP_004905417.1 HHA domain-containing protein Toxin
NTP66_RS03685 865504..865872 - 369 WP_004905413.1 Hha toxicity modulator TomB Antitoxin
NTP66_RS03690 866396..867766 - 1371 WP_136135575.1 murein transglycosylase D -
NTP66_RS03695 867848..868603 - 756 WP_140172117.1 hydroxyacylglutathione hydrolase -
NTP66_RS03700 868644..869378 + 735 WP_094962149.1 methyltransferase domain-containing protein -
NTP66_RS03705 869375..869845 - 471 WP_004905405.1 ribonuclease HI -
NTP66_RS03710 869900..870661 + 762 WP_140172118.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8061.34 Da        Isoelectric Point: 6.9770

>T273511 WP_004905417.1 NZ_CP118863:c865429-865226 [Providencia rettgeri]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14085.04 Da        Isoelectric Point: 4.4915

>AT273511 WP_004905413.1 NZ_CP118863:c865872-865504 [Providencia rettgeri]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSPQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWEAMNHSLVAVLDDDLKCLTSKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E6Q2

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6Q6D9

References