Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 744992..745531 Replicon chromosome
Accession NZ_CP118856
Organism Mammaliicoccus lentus strain 7046

Toxin (Protein)


Gene name mazF Uniprot ID A0A178P0V5
Locus tag PYH59_RS03720 Protein ID WP_016999692.1
Coordinates 745160..745531 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A4Y9KBD3
Locus tag PYH59_RS03715 Protein ID WP_016999693.1
Coordinates 744992..745159 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH59_RS03690 (PYH59_03690) 740853..741332 + 480 WP_282822110.1 PH domain-containing protein -
PYH59_RS03695 (PYH59_03695) 741322..742854 + 1533 WP_103268922.1 PH domain-containing protein -
PYH59_RS03700 (PYH59_03700) 742844..743344 + 501 WP_064204141.1 PH domain-containing protein -
PYH59_RS03705 (PYH59_03705) 743341..743709 + 369 WP_064204140.1 holo-ACP synthase -
PYH59_RS03710 (PYH59_03710) 743757..744905 + 1149 WP_103268921.1 alanine racemase -
PYH59_RS03715 (PYH59_03715) 744992..745159 + 168 WP_016999693.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PYH59_RS03720 (PYH59_03720) 745160..745531 + 372 WP_016999692.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PYH59_RS03725 (PYH59_03725) 745635..746639 + 1005 WP_064204137.1 PP2C family protein-serine/threonine phosphatase -
PYH59_RS03730 (PYH59_03730) 746712..747038 + 327 WP_016999690.1 anti-sigma factor antagonist -
PYH59_RS03735 (PYH59_03735) 747040..747516 + 477 WP_016999689.1 anti-sigma B factor RsbW -
PYH59_RS03740 (PYH59_03740) 747491..748261 + 771 WP_103268920.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13662.79 Da        Isoelectric Point: 9.8460

>T273508 WP_016999692.1 NZ_CP118856:745160-745531 [Mammaliicoccus lentus]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDSAIAISLNLTLQYKFDTLGNT

Download         Length: 372 bp

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6239.71 Da        Isoelectric Point: 4.0121

>AT273508 WP_016999693.1 NZ_CP118856:744992-745159 [Mammaliicoccus lentus]
MTSLTQNRNQSLEQTLKEGYRYMADLNLSLASEAYYSECEACDSNESHLTSQQGE

Download         Length: 168 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A178P0V5

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y9KBD3

References