Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2149959..2150498 Replicon chromosome
Accession NZ_CP118848
Organism Mammaliicoccus lentus strain 7048

Toxin (Protein)


Gene name mazF Uniprot ID A0A178P0V5
Locus tag PYH69_RS10905 Protein ID WP_016999692.1
Coordinates 2149959..2150330 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A4Y9KBD3
Locus tag PYH69_RS10910 Protein ID WP_016999693.1
Coordinates 2150331..2150498 (-) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH69_RS10885 (PYH69_10885) 2147229..2147999 - 771 WP_016999688.1 RNA polymerase sigma factor SigB -
PYH69_RS10890 (PYH69_10890) 2147974..2148450 - 477 WP_016999689.1 anti-sigma B factor RsbW -
PYH69_RS10895 (PYH69_10895) 2148452..2148778 - 327 WP_016999690.1 anti-sigma factor antagonist -
PYH69_RS10900 (PYH69_10900) 2148851..2149855 - 1005 WP_016999691.1 PP2C family protein-serine/threonine phosphatase -
PYH69_RS10905 (PYH69_10905) 2149959..2150330 - 372 WP_016999692.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PYH69_RS10910 (PYH69_10910) 2150331..2150498 - 168 WP_016999693.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PYH69_RS10915 (PYH69_10915) 2150585..2151733 - 1149 WP_016999694.1 alanine racemase -
PYH69_RS10920 (PYH69_10920) 2151781..2152149 - 369 WP_016999695.1 holo-ACP synthase -
PYH69_RS10925 (PYH69_10925) 2152146..2152646 - 501 WP_016999696.1 PH domain-containing protein -
PYH69_RS10930 (PYH69_10930) 2152636..2154168 - 1533 WP_282861853.1 PH domain-containing protein -
PYH69_RS10935 (PYH69_10935) 2154158..2154637 - 480 WP_282861854.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13662.79 Da        Isoelectric Point: 9.8460

>T273505 WP_016999692.1 NZ_CP118848:c2150330-2149959 [Mammaliicoccus lentus]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDSAIAISLNLTLQYKFDTLGNT

Download         Length: 372 bp

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6239.71 Da        Isoelectric Point: 4.0121

>AT273505 WP_016999693.1 NZ_CP118848:c2150498-2150331 [Mammaliicoccus lentus]
MTSLTQNRNQSLEQTLKEGYRYMADLNLSLASEAYYSECEACDSNESHLTSQQGE

Download         Length: 168 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A178P0V5

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y9KBD3

References