273503

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF-doc
Location 10579..11162 Replicon plasmid pML7049-4
Accession NZ_CP118846
Organism Staphylococcus epidermidis strain 7049

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag PYH64_RS12225 Protein ID WP_058703189.1
Coordinates 10824..11162 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag PYH64_RS12220 Protein ID WP_038978304.1
Coordinates 10579..10827 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH64_RS12195 (PYH64_12195) 7654..7983 + 330 WP_282872371.1 hypothetical protein -
PYH64_RS12200 (PYH64_12200) 8002..8244 + 243 WP_049367793.1 hypothetical protein -
PYH64_RS12205 (PYH64_12205) 8439..9221 + 783 WP_194375218.1 hypothetical protein -
PYH64_RS12210 (PYH64_12210) 9667..10212 + 546 WP_058703190.1 hypothetical protein -
PYH64_RS12215 (PYH64_12215) 10266..10400 + 135 WP_256948247.1 hypothetical protein -
PYH64_RS12220 (PYH64_12220) 10579..10827 + 249 WP_038978304.1 AbrB family transcriptional regulator Antitoxin
PYH64_RS12225 (PYH64_12225) 10824..11162 + 339 WP_058703189.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PYH64_RS12230 (PYH64_12230) 11307..11516 - 210 WP_058703188.1 hypothetical protein -
PYH64_RS12235 (PYH64_12235) 12010..12855 - 846 WP_000733268.1 penicillin-hydrolyzing class A beta-lactamase BlaZ -
PYH64_RS12240 (PYH64_12240) 12962..14719 + 1758 WP_001096392.1 beta-lactam sensor/signal transducer BlaR1 -
PYH64_RS12245 (PYH64_12245) 14709..15089 + 381 WP_001284653.1 penicillinase repressor BlaI -
PYH64_RS12250 (PYH64_12250) 15353..15931 + 579 WP_002455810.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(K) / blaZ / msr(A) - 1..41938 41938


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13106.20 Da        Isoelectric Point: 9.6404

>T273503 WP_058703189.1 NZ_CP118846:10824-11162 [Staphylococcus epidermidis]
MSIKQFDIYYIDLDPTRGREKQKIRPCLIVNNKMTIDGTNFVWALPITNREKRYPLDIEVKTKKGLVTGVIDTLQIRALD
LNEREHNYKDELQDNLKNVVLQAIKTYLKPSS

Download         Length: 339 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9176.31 Da        Isoelectric Point: 4.5463

>AT273503 WP_038978304.1 NZ_CP118846:10579-10827 [Staphylococcus epidermidis]
MIKTSERIFKSGNSKALSLSKQTIQLADFEVGDKVEVSEINGGLFIKKKEESIEDEITNFFKNGGKYTEPEIDFGESVGR
EI

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References