Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 993807..994609 Replicon chromosome
Accession NZ_CP118842
Organism Staphylococcus epidermidis strain 7049

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag PYH64_RS04830 Protein ID WP_002468490.1
Coordinates 994430..994609 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag PYH64_RS04825 Protein ID WP_002456349.1
Coordinates 993807..994406 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH64_RS04800 (PYH64_04800) 989018..990475 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
PYH64_RS04805 (PYH64_04805) 990468..991190 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
PYH64_RS04810 (PYH64_04810) 991705..991842 + 138 WP_064783702.1 hypothetical protein -
PYH64_RS04815 (PYH64_04815) 992052..993182 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
PYH64_RS04820 (PYH64_04820) 993179..993649 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
PYH64_RS04825 (PYH64_04825) 993807..994406 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
PYH64_RS04830 (PYH64_04830) 994430..994609 + 180 WP_002468490.1 SAS053 family protein Toxin
PYH64_RS04835 (PYH64_04835) 994765..995169 + 405 WP_001829818.1 hypothetical protein -
PYH64_RS04840 (PYH64_04840) 995354..996739 + 1386 WP_001829862.1 class II fumarate hydratase -
PYH64_RS04845 (PYH64_04845) 997100..997924 - 825 WP_001829804.1 RluA family pseudouridine synthase -
PYH64_RS04850 (PYH64_04850) 998083..999216 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T273500 WP_002468490.1 NZ_CP118842:994430-994609 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT273500 WP_002456349.1 NZ_CP118842:993807-994406 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References