273499

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 845247..845776 Replicon chromosome
Accession NZ_CP118842
Organism Staphylococcus epidermidis strain 7049

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag PYH64_RS03985 Protein ID WP_001829891.1
Coordinates 845414..845776 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag PYH64_RS03980 Protein ID WP_001829931.1
Coordinates 845247..845417 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH64_RS03955 (PYH64_03955) 841071..841550 + 480 WP_002457111.1 PH domain-containing protein -
PYH64_RS03960 (PYH64_03960) 841543..843048 + 1506 WP_002457110.1 PH domain-containing protein -
PYH64_RS03965 (PYH64_03965) 843035..843544 + 510 WP_002457109.1 PH domain-containing protein -
PYH64_RS03970 (PYH64_03970) 843592..843945 + 354 WP_002457108.1 holo-ACP synthase -
PYH64_RS03975 (PYH64_03975) 844012..845160 + 1149 WP_002457107.1 alanine racemase -
PYH64_RS03980 (PYH64_03980) 845247..845417 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PYH64_RS03985 (PYH64_03985) 845414..845776 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PYH64_RS03990 (PYH64_03990) 846121..847122 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
PYH64_RS03995 (PYH64_03995) 847222..847548 + 327 WP_001829952.1 anti-sigma factor antagonist -
PYH64_RS04000 (PYH64_04000) 847550..848029 + 480 WP_001829903.1 anti-sigma B factor RsbW -
PYH64_RS04005 (PYH64_04005) 848004..848774 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T273499 WP_001829891.1 NZ_CP118842:845414-845776 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT273499 WP_001829931.1 NZ_CP118842:845247-845417 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References