Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 834063..834572 Replicon chromosome
Accession NZ_CP118842
Organism Staphylococcus epidermidis strain 7049

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag PYH64_RS03925 Protein ID WP_001829980.1
Coordinates 834363..834572 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag PYH64_RS03920 Protein ID WP_001829893.1
Coordinates 834063..834356 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH64_RS03895 (PYH64_03895) 829071..829859 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
PYH64_RS03900 (PYH64_03900) 829865..830503 + 639 WP_032603408.1 thiamine phosphate synthase -
PYH64_RS03905 (PYH64_03905) 830592..831464 + 873 WP_002458703.1 membrane protein insertase YidC -
PYH64_RS03910 (PYH64_03910) 831570..832223 - 654 WP_001829983.1 HD domain-containing protein -
PYH64_RS03915 (PYH64_03915) 832405..833889 - 1485 WP_002457116.1 cardiolipin synthase -
PYH64_RS03920 (PYH64_03920) 834063..834356 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
PYH64_RS03925 (PYH64_03925) 834363..834572 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
PYH64_RS03930 (PYH64_03930) 834715..834852 + 138 WP_001829949.1 Lmo0850 family protein -
PYH64_RS03935 (PYH64_03935) 834951..836162 - 1212 WP_002486299.1 FtsW/RodA/SpoVE family cell cycle protein -
PYH64_RS03940 (PYH64_03940) 836553..837626 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
PYH64_RS03945 (PYH64_03945) 837638..838993 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T273498 WP_001829980.1 NZ_CP118842:834363-834572 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT273498 WP_001829893.1 NZ_CP118842:834063-834356 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References