Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 744991..745530 Replicon chromosome
Accession NZ_CP118837
Organism Mammaliicoccus lentus strain 7050

Toxin (Protein)


Gene name mazF Uniprot ID A0A178P0V5
Locus tag PYH50_RS03730 Protein ID WP_016999692.1
Coordinates 745159..745530 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A4Y9KBD3
Locus tag PYH50_RS03725 Protein ID WP_016999693.1
Coordinates 744991..745158 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH50_RS03700 (PYH50_03700) 740852..741331 + 480 WP_282822110.1 PH domain-containing protein -
PYH50_RS03705 (PYH50_03705) 741321..742853 + 1533 WP_103268922.1 PH domain-containing protein -
PYH50_RS03710 (PYH50_03710) 742843..743343 + 501 WP_064204141.1 PH domain-containing protein -
PYH50_RS03715 (PYH50_03715) 743340..743708 + 369 WP_064204140.1 holo-ACP synthase -
PYH50_RS03720 (PYH50_03720) 743756..744904 + 1149 WP_103268921.1 alanine racemase -
PYH50_RS03725 (PYH50_03725) 744991..745158 + 168 WP_016999693.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PYH50_RS03730 (PYH50_03730) 745159..745530 + 372 WP_016999692.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PYH50_RS03735 (PYH50_03735) 745634..746638 + 1005 WP_064204137.1 PP2C family protein-serine/threonine phosphatase -
PYH50_RS03740 (PYH50_03740) 746711..747037 + 327 WP_016999690.1 anti-sigma factor antagonist -
PYH50_RS03745 (PYH50_03745) 747039..747515 + 477 WP_016999689.1 anti-sigma B factor RsbW -
PYH50_RS03750 (PYH50_03750) 747490..748260 + 771 WP_103268920.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13662.79 Da        Isoelectric Point: 9.8460

>T273496 WP_016999692.1 NZ_CP118837:745159-745530 [Mammaliicoccus lentus]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDSAIAISLNLTLQYKFDTLGNT

Download         Length: 372 bp

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6239.71 Da        Isoelectric Point: 4.0121

>AT273496 WP_016999693.1 NZ_CP118837:744991-745158 [Mammaliicoccus lentus]
MTSLTQNRNQSLEQTLKEGYRYMADLNLSLASEAYYSECEACDSNESHLTSQQGE

Download         Length: 168 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A178P0V5

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y9KBD3

References