Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2123296..2123825 Replicon chromosome
Accession NZ_CP118835
Organism Staphylococcus aureus strain 7051

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PYH51_RS10550 Protein ID WP_000621175.1
Coordinates 2123296..2123658 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag PYH51_RS10555 Protein ID WP_000948331.1
Coordinates 2123655..2123825 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH51_RS10530 (2120274) 2120274..2121044 - 771 WP_001041102.1 RNA polymerase sigma factor SigB -
PYH51_RS10535 (2121019) 2121019..2121498 - 480 WP_001190829.1 anti-sigma B factor RsbW -
PYH51_RS10540 (2121500) 2121500..2121826 - 327 WP_001052491.1 anti-sigma factor antagonist -
PYH51_RS10545 (2121945) 2121945..2122946 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
PYH51_RS10550 (2123296) 2123296..2123658 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PYH51_RS10555 (2123655) 2123655..2123825 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PYH51_RS10560 (2123910) 2123910..2125058 - 1149 WP_001281154.1 alanine racemase -
PYH51_RS10565 (2125124) 2125124..2125483 - 360 WP_000581197.1 holo-ACP synthase -
PYH51_RS10570 (2125487) 2125487..2125978 - 492 WP_072353916.1 PH domain-containing protein -
PYH51_RS10575 (2125965) 2125965..2127548 - 1584 WP_045177766.1 PH domain-containing protein -
PYH51_RS10580 (2127541) 2127541..2128020 - 480 WP_001287079.1 hypothetical protein -
PYH51_RS10585 (2128229) 2128229..2128789 - 561 WP_001092409.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T273489 WP_000621175.1 NZ_CP118835:c2123658-2123296 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT273489 WP_000948331.1 NZ_CP118835:c2123825-2123655 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References