273469

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1925694..1926470 Replicon chromosome
Accession NZ_CP118832
Organism Staphylococcus aureus strain 7053

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag PYH65_RS09310 Protein ID WP_000031108.1
Coordinates 1925694..1925846 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag PYH65_RS09315 Protein ID WP_001251224.1
Coordinates 1925871..1926470 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH65_RS09295 (1921831) 1921831..1922652 + 822 WP_000669376.1 RluA family pseudouridine synthase -
PYH65_RS09300 (1923115) 1923115..1924500 - 1386 WP_000116229.1 class II fumarate hydratase -
PYH65_RS09305 (1924696) 1924696..1925091 - 396 WP_000901023.1 hypothetical protein -
PYH65_RS09310 (1925694) 1925694..1925846 - 153 WP_000031108.1 SAS053 family protein Toxin
PYH65_RS09315 (1925871) 1925871..1926470 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
PYH65_RS09320 (1926629) 1926629..1927099 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
PYH65_RS09325 (1927104) 1927104..1928231 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
PYH65_RS09330 (1928382) 1928382..1929104 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
PYH65_RS09335 (1929097) 1929097..1930554 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T273469 WP_000031108.1 NZ_CP118832:c1925846-1925694 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT273469 WP_001251224.1 NZ_CP118832:c1926470-1925871 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References