Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2143056..2143570 Replicon chromosome
Accession NZ_CP118830
Organism Staphylococcus aureus strain 7054

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag PYH54_RS10640 Protein ID WP_000581792.1
Coordinates 2143056..2143265 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag PYH54_RS10645 Protein ID WP_000138932.1
Coordinates 2143277..2143570 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH54_RS10620 (2138564) 2138564..2139922 - 1359 WP_045177762.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
PYH54_RS10625 (2139937) 2139937..2141007 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
PYH54_RS10630 (2141325) 2141325..2142527 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
PYH54_RS10635 (2142791) 2142791..2142928 - 138 WP_000828354.1 Lmo0850 family protein -
PYH54_RS10640 (2143056) 2143056..2143265 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
PYH54_RS10645 (2143277) 2143277..2143570 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
PYH54_RS10650 (2143736) 2143736..2145220 + 1485 WP_086095158.1 cardiolipin synthase -
PYH54_RS10655 (2145248) 2145248..2145895 + 648 WP_001187630.1 HD domain-containing protein -
PYH54_RS10660 (2146361) 2146361..2147233 - 873 WP_000725802.1 membrane protein insertase YidC -
PYH54_RS10665 (2147319) 2147319..2147960 - 642 WP_000483164.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T273460 WP_000581792.1 NZ_CP118830:c2143265-2143056 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT273460 WP_000138932.1 NZ_CP118830:c2143570-2143277 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References