Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2123298..2123827 Replicon chromosome
Accession NZ_CP118830
Organism Staphylococcus aureus strain 7054

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PYH54_RS10550 Protein ID WP_000621175.1
Coordinates 2123298..2123660 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag PYH54_RS10555 Protein ID WP_000948331.1
Coordinates 2123657..2123827 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH54_RS10530 (2120276) 2120276..2121046 - 771 WP_001041102.1 RNA polymerase sigma factor SigB -
PYH54_RS10535 (2121021) 2121021..2121500 - 480 WP_001190829.1 anti-sigma B factor RsbW -
PYH54_RS10540 (2121502) 2121502..2121828 - 327 WP_001052491.1 anti-sigma factor antagonist -
PYH54_RS10545 (2121947) 2121947..2122948 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
PYH54_RS10550 (2123298) 2123298..2123660 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PYH54_RS10555 (2123657) 2123657..2123827 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PYH54_RS10560 (2123912) 2123912..2125060 - 1149 WP_001281154.1 alanine racemase -
PYH54_RS10565 (2125126) 2125126..2125485 - 360 WP_000581197.1 holo-ACP synthase -
PYH54_RS10570 (2125489) 2125489..2125980 - 492 WP_072353916.1 PH domain-containing protein -
PYH54_RS10575 (2125967) 2125967..2127550 - 1584 WP_045177766.1 PH domain-containing protein -
PYH54_RS10580 (2127543) 2127543..2128022 - 480 WP_001287079.1 hypothetical protein -
PYH54_RS10585 (2128231) 2128231..2128791 - 561 WP_001092409.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T273459 WP_000621175.1 NZ_CP118830:c2123660-2123298 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT273459 WP_000948331.1 NZ_CP118830:c2123827-2123657 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References