Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1925695..1926471 Replicon chromosome
Accession NZ_CP118830
Organism Staphylococcus aureus strain 7054

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag PYH54_RS09305 Protein ID WP_000031108.1
Coordinates 1925695..1925847 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag PYH54_RS09310 Protein ID WP_001251224.1
Coordinates 1925872..1926471 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH54_RS09290 (1921832) 1921832..1922653 + 822 WP_000669376.1 RluA family pseudouridine synthase -
PYH54_RS09295 (1923116) 1923116..1924501 - 1386 WP_000116229.1 class II fumarate hydratase -
PYH54_RS09300 (1924697) 1924697..1925092 - 396 WP_000901023.1 hypothetical protein -
PYH54_RS09305 (1925695) 1925695..1925847 - 153 WP_000031108.1 SAS053 family protein Toxin
PYH54_RS09310 (1925872) 1925872..1926471 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
PYH54_RS09315 (1926630) 1926630..1927100 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
PYH54_RS09320 (1927105) 1927105..1928232 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
PYH54_RS09325 (1928383) 1928383..1929105 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
PYH54_RS09330 (1929098) 1929098..1930555 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T273454 WP_000031108.1 NZ_CP118830:c1925847-1925695 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT273454 WP_001251224.1 NZ_CP118830:c1926471-1925872 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References