Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1030324..1031129 Replicon chromosome
Accession NZ_CP118820
Organism Staphylococcus epidermidis strain 7057

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag PYH56_RS04980 Protein ID WP_002457885.1
Coordinates 1030947..1031129 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0E1VBD1
Locus tag PYH56_RS04975 Protein ID WP_002446763.1
Coordinates 1030324..1030923 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH56_RS04955 (PYH56_04955) 1026049..1027506 + 1458 WP_060545923.1 ABC transporter substrate-binding protein/permease -
PYH56_RS04960 (PYH56_04960) 1027499..1028221 + 723 WP_002446766.1 amino acid ABC transporter ATP-binding protein -
PYH56_RS04965 (PYH56_04965) 1028569..1029699 + 1131 WP_002476052.1 tRNA epoxyqueuosine(34) reductase QueG -
PYH56_RS04970 (PYH56_04970) 1029696..1030166 + 471 WP_162154432.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
PYH56_RS04975 (PYH56_04975) 1030324..1030923 + 600 WP_002446763.1 glucosamine-6-phosphate isomerase Antitoxin
PYH56_RS04980 (PYH56_04980) 1030947..1031129 + 183 WP_002457885.1 SAS053 family protein Toxin
PYH56_RS04985 (PYH56_04985) 1031281..1031685 + 405 WP_002457884.1 hypothetical protein -
PYH56_RS04990 (PYH56_04990) 1031877..1033262 + 1386 WP_002447846.1 class II fumarate hydratase -
PYH56_RS04995 (PYH56_04995) 1033738..1034220 + 483 Protein_950 transposase -
PYH56_RS05000 (PYH56_05000) 1034394..1035218 - 825 WP_002457882.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1033909..1034220 311


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7080.67 Da        Isoelectric Point: 4.3016

>T273449 WP_002457885.1 NZ_CP118820:1030947-1031129 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQPHDNEVRSDFKNSK

Download         Length: 183 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22635.54 Da        Isoelectric Point: 4.9942

>AT273449 WP_002446763.1 NZ_CP118820:1030324-1030923 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLGKEHAPVFDELKKNVENHAVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDVSVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VBD1

References