Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 889778..890307 Replicon chromosome
Accession NZ_CP118820
Organism Staphylococcus epidermidis strain 7057

Toxin (Protein)


Gene name mazF Uniprot ID A0A939SRT1
Locus tag PYH56_RS04165 Protein ID WP_002447757.1
Coordinates 889945..890307 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag PYH56_RS04160 Protein ID WP_001829931.1
Coordinates 889778..889948 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH56_RS04135 (PYH56_04135) 885602..886081 + 480 WP_038813238.1 PH domain-containing protein -
PYH56_RS04140 (PYH56_04140) 886074..887579 + 1506 WP_038813239.1 PH domain-containing protein -
PYH56_RS04145 (PYH56_04145) 887566..888084 + 519 WP_002499547.1 PH domain-containing protein -
PYH56_RS04150 (PYH56_04150) 888123..888476 + 354 WP_002486941.1 holo-ACP synthase -
PYH56_RS04155 (PYH56_04155) 888543..889691 + 1149 WP_002458690.1 alanine racemase -
PYH56_RS04160 (PYH56_04160) 889778..889948 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PYH56_RS04165 (PYH56_04165) 889945..890307 + 363 WP_002447757.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PYH56_RS04170 (PYH56_04170) 890652..891653 + 1002 WP_046044500.1 PP2C family protein-serine/threonine phosphatase -
PYH56_RS04175 (PYH56_04175) 891753..892079 + 327 WP_001829952.1 anti-sigma factor antagonist -
PYH56_RS04180 (PYH56_04180) 892081..892560 + 480 WP_001829903.1 anti-sigma B factor RsbW -
PYH56_RS04185 (PYH56_04185) 892535..893305 + 771 WP_002458689.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13483.62 Da        Isoelectric Point: 9.9522

>T273448 WP_002447757.1 NZ_CP118820:889945-890307 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSDSKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT273448 WP_001829931.1 NZ_CP118820:889778-889948 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References