Detailed information of TA system TA273448

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 889778..890307
• Replicon: chromosome
• Accession: NZ_CP118820
• Organism: Staphylococcus epidermidis strain 7057

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A0A939SRT1
• Locus tag: PYH56_RS04165
• Protein ID: WP_002447757.1
• Coordinates: 889945..890307 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: Q5HME6
• Locus tag: PYH56_RS04160
• Protein ID: WP_001829931.1
• Coordinates: 889778..889948 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-109)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13483.62 Da
• Isoelectric Point: 9.9522

>T273448 WP_002447757.1 NZ_CP118820:889945-890307 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSDSKMIEVDNALDISLGLNNFDHHKS

Nucleotide

• Length: 363 bp

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6289.92 Da
• Isoelectric Point: 4.1920

>AT273448 WP_001829931.1 NZ_CP118820:889778-889948 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Nucleotide

• Length: 171 bp

Structures

Antitoxin

• AlphaFold DB: A0A0N1EF65