Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 878593..879102 Replicon chromosome
Accession NZ_CP118820
Organism Staphylococcus epidermidis strain 7057

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0E1VPY9
Locus tag PYH56_RS04105 Protein ID WP_002447767.1
Coordinates 878893..879102 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A829M395
Locus tag PYH56_RS04100 Protein ID WP_002458700.1
Coordinates 878593..878886 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH56_RS04075 (PYH56_04075) 873600..874388 + 789 WP_020363517.1 hydroxyethylthiazole kinase -
PYH56_RS04080 (PYH56_04080) 874394..875032 + 639 WP_002458704.1 thiamine phosphate synthase -
PYH56_RS04085 (PYH56_04085) 875121..875993 + 873 WP_002458703.1 membrane protein insertase YidC -
PYH56_RS04090 (PYH56_04090) 876100..876753 - 654 WP_002458702.1 HD domain-containing protein -
PYH56_RS04095 (PYH56_04095) 876935..878419 - 1485 WP_002458701.1 cardiolipin synthase -
PYH56_RS04100 (PYH56_04100) 878593..878886 + 294 WP_002458700.1 copper-sensing transcriptional repressor CsoR Antitoxin
PYH56_RS04105 (PYH56_04105) 878893..879102 + 210 WP_002447767.1 cation transporter Toxin
PYH56_RS04110 (PYH56_04110) 879245..879382 + 138 WP_001829949.1 Lmo0850 family protein -
PYH56_RS04115 (PYH56_04115) 879480..880691 - 1212 WP_002447766.1 FtsW/RodA/SpoVE family cell cycle protein -
PYH56_RS04120 (PYH56_04120) 881082..882155 + 1074 WP_038813237.1 D-alanine--D-alanine ligase -
PYH56_RS04125 (PYH56_04125) 882167..883522 + 1356 WP_002458697.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(10-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 8008.28 Da        Isoelectric Point: 6.4556

>T273447 WP_002447767.1 NZ_CP118820:878893-879102 [Staphylococcus epidermidis]
MKLKKGLIHVSGIKTTEQEKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDCGFRIL

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11082.71 Da        Isoelectric Point: 5.5778

>AT273447 WP_002458700.1 NZ_CP118820:878593-878886 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVAIKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VPY9

Antitoxin

Source ID Structure
AlphaFold DB A0A829M395

References