Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tsbAT/- |
| Location | 996051..996853 | Replicon | chromosome |
| Accession | NZ_CP118814 | ||
| Organism | Staphylococcus epidermidis strain 7060 | ||
Toxin (Protein)
| Gene name | tsbT | Uniprot ID | Q5HN83 |
| Locus tag | PYH74_RS04805 | Protein ID | WP_002468490.1 |
| Coordinates | 996674..996853 (+) | Length | 60 a.a. |
Antitoxin (Protein)
| Gene name | tsbA | Uniprot ID | Q5HN82 |
| Locus tag | PYH74_RS04800 | Protein ID | WP_002456349.1 |
| Coordinates | 996051..996650 (+) | Length | 200 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PYH74_RS04775 (PYH74_04775) | 991262..992719 | + | 1458 | WP_002440300.1 | ABC transporter substrate-binding protein/permease | - |
| PYH74_RS04780 (PYH74_04780) | 992712..993434 | + | 723 | WP_001829838.1 | amino acid ABC transporter ATP-binding protein | - |
| PYH74_RS04785 (PYH74_04785) | 993949..994086 | + | 138 | WP_064783702.1 | hypothetical protein | - |
| PYH74_RS04790 (PYH74_04790) | 994296..995426 | + | 1131 | WP_001829814.1 | tRNA epoxyqueuosine(34) reductase QueG | - |
| PYH74_RS04795 (PYH74_04795) | 995423..995893 | + | 471 | WP_001829836.1 | tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL | - |
| PYH74_RS04800 (PYH74_04800) | 996051..996650 | + | 600 | WP_002456349.1 | glucosamine-6-phosphate isomerase | Antitoxin |
| PYH74_RS04805 (PYH74_04805) | 996674..996853 | + | 180 | WP_002468490.1 | SAS053 family protein | Toxin |
| PYH74_RS04810 (PYH74_04810) | 997009..997413 | + | 405 | WP_001829818.1 | hypothetical protein | - |
| PYH74_RS04815 (PYH74_04815) | 997598..998983 | + | 1386 | WP_001829862.1 | class II fumarate hydratase | - |
| PYH74_RS04820 (PYH74_04820) | 999344..1000168 | - | 825 | WP_001829804.1 | RluA family pseudouridine synthase | - |
| PYH74_RS04825 (PYH74_04825) | 1000327..1001460 | + | 1134 | WP_001829819.1 | GAF domain-containing sensor histidine kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6963.56 Da Isoelectric Point: 4.3016
>T273445 WP_002468490.1 NZ_CP118814:996674-996853 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ
Download Length: 180 bp
Antitoxin
Download Length: 200 a.a. Molecular weight: 22709.62 Da Isoelectric Point: 4.9942
>AT273445 WP_002456349.1 NZ_CP118814:996051-996650 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA
Download Length: 600 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2G7HY44 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5E9LUD0 |