Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 847435..847964 Replicon chromosome
Accession NZ_CP118814
Organism Staphylococcus epidermidis strain 7060

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag PYH74_RS03960 Protein ID WP_001829891.1
Coordinates 847602..847964 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag PYH74_RS03955 Protein ID WP_001829931.1
Coordinates 847435..847605 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH74_RS03930 (PYH74_03930) 843262..843741 + 480 WP_001829909.1 PH domain-containing protein -
PYH74_RS03935 (PYH74_03935) 843734..845239 + 1506 WP_001829976.1 PH domain-containing protein -
PYH74_RS03940 (PYH74_03940) 845226..845735 + 510 WP_001829888.1 PH domain-containing protein -
PYH74_RS03945 (PYH74_03945) 845783..846136 + 354 WP_001829915.1 holo-ACP synthase -
PYH74_RS03950 (PYH74_03950) 846200..847348 + 1149 WP_002468951.1 alanine racemase -
PYH74_RS03955 (PYH74_03955) 847435..847605 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PYH74_RS03960 (PYH74_03960) 847602..847964 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PYH74_RS03965 (PYH74_03965) 848310..849311 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
PYH74_RS03970 (PYH74_03970) 849411..849737 + 327 WP_001829952.1 anti-sigma factor antagonist -
PYH74_RS03975 (PYH74_03975) 849739..850218 + 480 WP_001829903.1 anti-sigma B factor RsbW -
PYH74_RS03980 (PYH74_03980) 850193..850963 + 771 WP_002468952.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T273444 WP_001829891.1 NZ_CP118814:847602-847964 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT273444 WP_001829931.1 NZ_CP118814:847435-847605 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References