Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 836254..836763 Replicon chromosome
Accession NZ_CP118814
Organism Staphylococcus epidermidis strain 7060

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag PYH74_RS03900 Protein ID WP_001829980.1
Coordinates 836554..836763 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag PYH74_RS03895 Protein ID WP_001829893.1
Coordinates 836254..836547 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH74_RS03870 (PYH74_03870) 831262..832050 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
PYH74_RS03875 (PYH74_03875) 832056..832694 + 639 WP_002505076.1 thiamine phosphate synthase -
PYH74_RS03880 (PYH74_03880) 832783..833655 + 873 WP_002458703.1 membrane protein insertase YidC -
PYH74_RS03885 (PYH74_03885) 833761..834414 - 654 WP_001829983.1 HD domain-containing protein -
PYH74_RS03890 (PYH74_03890) 834596..836080 - 1485 WP_002457116.1 cardiolipin synthase -
PYH74_RS03895 (PYH74_03895) 836254..836547 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
PYH74_RS03900 (PYH74_03900) 836554..836763 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
PYH74_RS03905 (PYH74_03905) 836906..837043 + 138 WP_001829949.1 Lmo0850 family protein -
PYH74_RS03910 (PYH74_03910) 837143..838354 - 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
PYH74_RS03915 (PYH74_03915) 838745..839818 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
PYH74_RS03920 (PYH74_03920) 839830..841185 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T273443 WP_001829980.1 NZ_CP118814:836554-836763 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT273443 WP_001829893.1 NZ_CP118814:836254-836547 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References