273441

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 744994..745533 Replicon chromosome
Accession NZ_CP118800
Organism Mammaliicoccus lentus strain 7066

Toxin (Protein)


Gene name mazF Uniprot ID A0A178P0V5
Locus tag PYH60_RS03725 Protein ID WP_016999692.1
Coordinates 745162..745533 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A4Y9KBD3
Locus tag PYH60_RS03720 Protein ID WP_016999693.1
Coordinates 744994..745161 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH60_RS03695 (PYH60_03695) 740855..741334 + 480 WP_282822110.1 PH domain-containing protein -
PYH60_RS03700 (PYH60_03700) 741324..742856 + 1533 WP_103268922.1 PH domain-containing protein -
PYH60_RS03705 (PYH60_03705) 742846..743346 + 501 WP_064204141.1 PH domain-containing protein -
PYH60_RS03710 (PYH60_03710) 743343..743711 + 369 WP_064204140.1 holo-ACP synthase -
PYH60_RS03715 (PYH60_03715) 743759..744907 + 1149 WP_103268921.1 alanine racemase -
PYH60_RS03720 (PYH60_03720) 744994..745161 + 168 WP_016999693.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PYH60_RS03725 (PYH60_03725) 745162..745533 + 372 WP_016999692.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PYH60_RS03730 (PYH60_03730) 745637..746641 + 1005 WP_064204137.1 PP2C family protein-serine/threonine phosphatase -
PYH60_RS03735 (PYH60_03735) 746714..747040 + 327 WP_016999690.1 anti-sigma factor antagonist -
PYH60_RS03740 (PYH60_03740) 747042..747518 + 477 WP_016999689.1 anti-sigma B factor RsbW -
PYH60_RS03745 (PYH60_03745) 747493..748263 + 771 WP_103268920.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13662.79 Da        Isoelectric Point: 9.8460

>T273441 WP_016999692.1 NZ_CP118800:745162-745533 [Mammaliicoccus lentus]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDSAIAISLNLTLQYKFDTLGNT

Download         Length: 372 bp

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6239.71 Da        Isoelectric Point: 4.0121

>AT273441 WP_016999693.1 NZ_CP118800:744994-745161 [Mammaliicoccus lentus]
MTSLTQNRNQSLEQTLKEGYRYMADLNLSLASEAYYSECEACDSNESHLTSQQGE

Download         Length: 168 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A178P0V5

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y9KBD3

References