Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3223533..3224242 Replicon chromosome
Accession NZ_CP118775
Organism Delftia tsuruhatensis strain ULwDis3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PW274_RS15215 Protein ID WP_126312062.1
Coordinates 3223533..3223979 (-) Length 149 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A072T8L1
Locus tag PW274_RS15220 Protein ID WP_043790233.1
Coordinates 3223976..3224242 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PW274_RS15195 (PW274_15195) 3219131..3220345 + 1215 WP_047219430.1 ABC transporter permease -
PW274_RS15200 (PW274_15200) 3220347..3221492 + 1146 WP_016453267.1 ABC transporter permease -
PW274_RS15205 (PW274_15205) 3221556..3222185 - 630 WP_126312061.1 DUF4124 domain-containing protein -
PW274_RS15210 (PW274_15210) 3222264..3223469 - 1206 WP_013801714.1 MFS transporter -
PW274_RS15215 (PW274_15215) 3223533..3223979 - 447 WP_126312062.1 type II toxin-antitoxin system VapC family toxin Toxin
PW274_RS15220 (PW274_15220) 3223976..3224242 - 267 WP_043790233.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PW274_RS15225 (PW274_15225) 3224267..3225238 - 972 WP_126312063.1 LysR family transcriptional regulator -
PW274_RS15230 (PW274_15230) 3225315..3226199 + 885 WP_193615971.1 amidohydrolase family protein -
PW274_RS15235 (PW274_15235) 3226226..3227221 + 996 WP_126312065.1 tripartite tricarboxylate transporter substrate binding protein -
PW274_RS15240 (PW274_15240) 3227247..3228878 - 1632 WP_126312066.1 gamma-glutamyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-133)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 15884.45 Da        Isoelectric Point: 8.1045

>T273435 WP_126312062.1 NZ_CP118775:c3223979-3223533 [Delftia tsuruhatensis]
MTRYLLDTNIASHIIKGDIPAVREQLVRVPMHQIAVSAVTQAELMYGVAKRGHPAGLSLRVTGFLARVEVLPWTAQVADA
YGHLRAACEAAGITLASMDMMIAAHALFLQQQAAQAGERSVLVTRDRVFSRIPEPGLAIADWTTGPAG

Download         Length: 447 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10060.08 Da        Isoelectric Point: 4.3846

>AT273435 WP_043790233.1 NZ_CP118775:c3224242-3223976 [Delftia tsuruhatensis]
VTQTAKLFTTGRSQAVRLPYEFRFEEKEVYIRRDPITGDVILSRRPDSWQEFFALDATTDVPADFMDTADRAQPESGRDP
FADEGSAR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A072T8L1

References