Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3631739..3632359 Replicon chromosome
Accession NZ_CP118774
Organism Citrobacter braakii strain ASE1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag PXN04_RS17435 Protein ID WP_002892050.1
Coordinates 3632141..3632359 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7L6U5G9
Locus tag PXN04_RS17430 Protein ID WP_019076175.1
Coordinates 3631739..3632113 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXN04_RS17420 (PXN04_17420) 3626886..3628079 + 1194 WP_016152074.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PXN04_RS17425 (PXN04_17425) 3628102..3631251 + 3150 WP_016152073.1 efflux RND transporter permease AcrB -
PXN04_RS17430 (PXN04_17430) 3631739..3632113 + 375 WP_019076175.1 Hha toxicity modulator TomB Antitoxin
PXN04_RS17435 (PXN04_17435) 3632141..3632359 + 219 WP_002892050.1 HHA domain-containing protein Toxin
PXN04_RS17440 (PXN04_17440) 3632540..3633091 + 552 WP_046276082.1 maltose O-acetyltransferase -
PXN04_RS17445 (PXN04_17445) 3633208..3633678 + 471 WP_016152071.1 YlaC family protein -
PXN04_RS17450 (PXN04_17450) 3633756..3633896 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
PXN04_RS17455 (PXN04_17455) 3633898..3634158 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
PXN04_RS17460 (PXN04_17460) 3634347..3635900 + 1554 WP_053388979.1 EAL domain-containing protein -
PXN04_RS17465 (PXN04_17465) 3635952..3636305 - 354 WP_003831033.1 DUF1428 family protein -
PXN04_RS17470 (PXN04_17470) 3636370..3636999 - 630 WP_016155872.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T273428 WP_002892050.1 NZ_CP118774:3632141-3632359 [Citrobacter braakii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14413.20 Da        Isoelectric Point: 5.5653

>AT273428 WP_019076175.1 NZ_CP118774:3631739-3632113 [Citrobacter braakii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6U5G9

References