Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2331233..2331869 Replicon chromosome
Accession NZ_CP118774
Organism Citrobacter braakii strain ASE1

Toxin (Protein)


Gene name hicA Uniprot ID A0A2I8S6E9
Locus tag PXN04_RS11090 Protein ID WP_049259794.1
Coordinates 2331233..2331421 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PXN04_RS11095 Protein ID WP_131382557.1
Coordinates 2331453..2331869 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXN04_RS11070 (PXN04_11070) 2328011..2328241 - 231 WP_016156585.1 DUF2554 family protein -
PXN04_RS11075 (PXN04_11075) 2328431..2328556 - 126 WP_003020230.1 DUF2474 domain-containing protein -
PXN04_RS11080 (PXN04_11080) 2328556..2329566 - 1011 WP_016153157.1 cytochrome d ubiquinol oxidase subunit II -
PXN04_RS11085 (PXN04_11085) 2329566..2330969 - 1404 WP_047417372.1 cytochrome ubiquinol oxidase subunit I -
PXN04_RS11090 (PXN04_11090) 2331233..2331421 + 189 WP_049259794.1 type II toxin-antitoxin system HicA family toxin Toxin
PXN04_RS11095 (PXN04_11095) 2331453..2331869 + 417 WP_131382557.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PXN04_RS11100 (PXN04_11100) 2331962..2333371 + 1410 WP_019076828.1 PLP-dependent aminotransferase family protein -
PXN04_RS11105 (PXN04_11105) 2333701..2334846 + 1146 WP_016153154.1 ABC transporter substrate-binding protein -
PXN04_RS11110 (PXN04_11110) 2334863..2335879 + 1017 WP_016153153.1 ABC transporter ATP-binding protein -
PXN04_RS11115 (PXN04_11115) 2335880..2336824 + 945 WP_016153152.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7102.16 Da        Isoelectric Point: 11.5775

>T273423 WP_049259794.1 NZ_CP118774:2331233-2331421 [Citrobacter braakii]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKSILKQLGLQSSSI

Download         Length: 189 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15064.33 Da        Isoelectric Point: 4.7119

>AT273423 WP_131382557.1 NZ_CP118774:2331453-2331869 [Citrobacter braakii]
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHGALQAAQSALVTAFEFYFDDNEPIPLPSAVGTEGDYVEIPLSIASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S6E9

Antitoxin

Source ID Structure

References