Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 897271..897925 Replicon chromosome
Accession NZ_CP118774
Organism Citrobacter braakii strain ASE1

Toxin (Protein)


Gene name cptA Uniprot ID R8WN60
Locus tag PXN04_RS04425 Protein ID WP_016154348.1
Coordinates 897518..897925 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag PXN04_RS04420 Protein ID WP_016154349.1
Coordinates 897271..897537 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXN04_RS04395 (PXN04_04395) 892484..893917 - 1434 WP_016154353.1 6-phospho-beta-glucosidase BglA -
PXN04_RS04400 (PXN04_04400) 894038..894766 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
PXN04_RS04405 (PXN04_04405) 894819..895130 + 312 WP_016154352.1 N(4)-acetylcytidine aminohydrolase -
PXN04_RS04410 (PXN04_04410) 895294..895953 + 660 WP_016154351.1 hemolysin III family protein -
PXN04_RS04415 (PXN04_04415) 896033..897013 - 981 WP_137352061.1 tRNA-modifying protein YgfZ -
PXN04_RS04420 (PXN04_04420) 897271..897537 + 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
PXN04_RS04425 (PXN04_04425) 897518..897925 + 408 WP_016154348.1 protein YgfX Toxin
PXN04_RS04430 (PXN04_04430) 898026..898547 - 522 WP_169329850.1 flavodoxin FldB -
PXN04_RS04435 (PXN04_04435) 898661..899557 + 897 WP_016154346.1 site-specific tyrosine recombinase XerD -
PXN04_RS04440 (PXN04_04440) 899581..900294 + 714 WP_047414418.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PXN04_RS04445 (PXN04_04445) 900300..902033 + 1734 WP_016157413.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15850.66 Da        Isoelectric Point: 11.2845

>T273422 WP_016154348.1 NZ_CP118774:897518-897925 [Citrobacter braakii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIASAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLILQQAKQG

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT273422 WP_016154349.1 NZ_CP118774:897271-897537 [Citrobacter braakii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8WN60

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References