Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2755533..2756104 Replicon chromosome
Accession NZ_CP118755
Organism Enterococcus faecalis strain W5

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PWA41_RS13345 Protein ID WP_002354774.1
Coordinates 2755533..2755874 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag PWA41_RS13350 Protein ID WP_002354773.1
Coordinates 2755874..2756104 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWA41_RS13340 (2751548) 2751548..2755162 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
PWA41_RS13345 (2755533) 2755533..2755874 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PWA41_RS13350 (2755874) 2755874..2756104 - 231 WP_002354773.1 hypothetical protein Antitoxin
PWA41_RS13355 (2756518) 2756518..2756733 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
PWA41_RS13360 (2756872) 2756872..2757864 + 993 WP_016632734.1 biotin--[acetyl-CoA-carboxylase] ligase -
PWA41_RS13365 (2757931) 2757931..2758563 - 633 WP_002358972.1 RloB family protein -
PWA41_RS13370 (2758572) 2758572..2759867 - 1296 WP_275016500.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T273411 WP_002354774.1 NZ_CP118755:c2755874-2755533 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT273411 WP_002354773.1 NZ_CP118755:c2756104-2755874 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References