Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ImmA-IrrE/HTH_19(antitoxin) |
| Location | 143341..144360 | Replicon | chromosome |
| Accession | NZ_CP118755 | ||
| Organism | Enterococcus faecalis strain W5 | ||
Toxin (Protein)
| Gene name | IrrE | Uniprot ID | - |
| Locus tag | PWA41_RS00615 | Protein ID | WP_137274387.1 |
| Coordinates | 143341..143979 (-) | Length | 213 a.a. |
Antitoxin (Protein)
| Gene name | ImmA | Uniprot ID | - |
| Locus tag | PWA41_RS00620 | Protein ID | WP_002359284.1 |
| Coordinates | 143986..144360 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PWA41_RS00605 (141231) | 141231..142129 | + | 899 | Protein_120 | tyrosine-type recombinase/integrase | - |
| PWA41_RS00610 (142724) | 142724..143299 | + | 576 | WP_002359282.1 | restriction endonuclease | - |
| PWA41_RS00615 (143341) | 143341..143979 | - | 639 | WP_137274387.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
| PWA41_RS00620 (143986) | 143986..144360 | - | 375 | WP_002359284.1 | helix-turn-helix domain-containing protein | Antitoxin |
| PWA41_RS00625 (145552) | 145552..145821 | + | 270 | WP_265615502.1 | hypothetical protein | - |
| PWA41_RS00630 (145891) | 145891..146217 | + | 327 | WP_002359288.1 | hypothetical protein | - |
| PWA41_RS00635 (146217) | 146217..146624 | + | 408 | WP_002359289.1 | DUF961 family protein | - |
| PWA41_RS00640 (146779) | 146779..147003 | + | 225 | WP_137274389.1 | hypothetical protein | - |
| PWA41_RS00645 (147032) | 147032..147223 | + | 192 | WP_137274394.1 | hypothetical protein | - |
| PWA41_RS00650 (147205) | 147205..147609 | + | 405 | WP_137274390.1 | hypothetical protein | - |
| PWA41_RS00655 (147721) | 147721..148053 | + | 333 | WP_137274391.1 | nucleotidyltransferase domain-containing protein | - |
| PWA41_RS00660 (148043) | 148043..148426 | + | 384 | WP_002359294.1 | DUF86 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 99429..181424 | 81995 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 213 a.a. Molecular weight: 25202.20 Da Isoelectric Point: 9.1676
>T273400 WP_137274387.1 NZ_CP118755:c143979-143341 [Enterococcus faecalis]
MILNKKKLYFETQAFTDKLINEISINMSKRKELINCYDIEAYVKETENIDFFDYPFKKQSKKLIWGSVTKIGDVTMVATA
QHLKIEIKNFTKMHEIIHHYFDYTTDIPNNEKSFDTLLIKKGYLPEDYPKEFRANKGAGMLLINKKALKYAFSTYDDLEK
MASFFNVNDIVLKIRILDELIYSHNLSYKQANLIYNSYYFQQQTQLKEILFK
MILNKKKLYFETQAFTDKLINEISINMSKRKELINCYDIEAYVKETENIDFFDYPFKKQSKKLIWGSVTKIGDVTMVATA
QHLKIEIKNFTKMHEIIHHYFDYTTDIPNNEKSFDTLLIKKGYLPEDYPKEFRANKGAGMLLINKKALKYAFSTYDDLEK
MASFFNVNDIVLKIRILDELIYSHNLSYKQANLIYNSYYFQQQTQLKEILFK
Download Length: 639 bp
Antitoxin
Download Length: 125 a.a. Molecular weight: 14518.29 Da Isoelectric Point: 4.8896
>AT273400 WP_002359284.1 NZ_CP118755:c144360-143986 [Enterococcus faecalis]
MKTYEKIKQLRENREITQKEISNALDINVSVYNKIELGIRPLREEELTAIADFFNVSIDYLTGRTDNPTTPSNNQKEAGQ
NIISHFRLNTNDLSSDDIEELEKELIDFQEFLIKRAKERKKKSE
MKTYEKIKQLRENREITQKEISNALDINVSVYNKIELGIRPLREEELTAIADFFNVSIDYLTGRTDNPTTPSNNQKEAGQ
NIISHFRLNTNDLSSDDIEELEKELIDFQEFLIKRAKERKKKSE
Download Length: 375 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|