Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2541118..2541683 Replicon chromosome
Accession NZ_CP118745
Organism Lactiplantibacillus paraplantarum strain FL-8

Toxin (Protein)


Gene name mazF Uniprot ID F9URY0
Locus tag PWO93_RS12050 Protein ID WP_011101950.1
Coordinates 2541118..2541465 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID F9URY1
Locus tag PWO93_RS12055 Protein ID WP_011101951.1
Coordinates 2541465..2541683 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWO93_RS12025 (PWO93_12025) 2537201..2537839 - 639 WP_275090993.1 NAD(P)H-binding protein -
PWO93_RS12030 (PWO93_12030) 2538191..2538634 - 444 WP_275090994.1 universal stress protein -
PWO93_RS12035 (PWO93_12035) 2538706..2539275 - 570 WP_275090995.1 sugar O-acetyltransferase -
PWO93_RS12040 (PWO93_12040) 2539372..2540055 + 684 WP_275090996.1 YjjG family noncanonical pyrimidine nucleotidase -
PWO93_RS12045 (PWO93_12045) 2540181..2540696 - 516 WP_275090997.1 hypothetical protein -
PWO93_RS12050 (PWO93_12050) 2541118..2541465 - 348 WP_011101950.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PWO93_RS12055 (PWO93_12055) 2541465..2541683 - 219 WP_011101951.1 hypothetical protein Antitoxin
PWO93_RS12060 (PWO93_12060) 2542424..2542939 - 516 WP_275090998.1 hypothetical protein -
PWO93_RS12065 (PWO93_12065) 2543153..2543431 - 279 WP_131510272.1 hypothetical protein -
PWO93_RS12070 (PWO93_12070) 2543932..2544525 - 594 WP_275090999.1 NAD(P)-binding domain-containing protein -
PWO93_RS12075 (PWO93_12075) 2544674..2545846 - 1173 WP_275091000.1 MalY/PatB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-107)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13274.06 Da        Isoelectric Point: 9.5016

>T273399 WP_011101950.1 NZ_CP118745:c2541465-2541118 [Lactiplantibacillus paraplantarum]
MTYLPKQKDIIWIDFDPQRGREIKKRRPAVVLSSNLYTQNTGFVIVSPITSTMRDLPGYFSLNGYNTHGQIAAAQIYSFD
ATPRAGRSITYIETMRSADFYHVAQTVYYNFDFPF

Download         Length: 348 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8163.27 Da        Isoelectric Point: 8.5318

>AT273399 WP_011101951.1 NZ_CP118745:c2541683-2541465 [Lactiplantibacillus paraplantarum]
MIEVKTVSRGNSLALSLPKDGRFKKGQRWLLIPSSDGESYTLVPRIENPYAGSKPKRPMTEAWSDVDWNEVE

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F9URY0

Antitoxin

Source ID Structure
AlphaFold DB F9URY1

References