273398

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1428027..1428946 Replicon chromosome
Accession NZ_CP118744
Organism Bacillus paralicheniformis strain RP01

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A6I7TYV7
Locus tag PWG69_RS07200 Protein ID WP_023856735.1
Coordinates 1428200..1428946 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A6I7TM13
Locus tag PWG69_RS07195 Protein ID WP_023856734.1
Coordinates 1428027..1428200 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWG69_RS07170 (PWG69_07170) 1423452..1424549 + 1098 WP_025811596.1 mannonate dehydratase -
PWG69_RS07175 (PWG69_07175) 1424525..1425373 + 849 WP_025811594.1 SDR family oxidoreductase -
PWG69_RS07180 (PWG69_07180) 1425399..1426412 + 1014 WP_025811592.1 zinc-binding alcohol dehydrogenase family protein -
PWG69_RS07185 (PWG69_07185) 1426464..1427735 + 1272 WP_025811590.1 MFS transporter -
PWG69_RS07190 (PWG69_07190) 1427802..1427933 - 132 WP_023856733.1 hypothetical protein -
PWG69_RS07195 (PWG69_07195) 1428027..1428200 - 174 WP_023856734.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
PWG69_RS07200 (PWG69_07200) 1428200..1428946 - 747 WP_023856735.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
PWG69_RS07205 (PWG69_07205) 1429056..1430054 - 999 WP_023856736.1 inorganic phosphate transporter -
PWG69_RS07210 (PWG69_07210) 1430067..1430684 - 618 WP_023856737.1 DUF47 domain-containing protein -
PWG69_RS07215 (PWG69_07215) 1431017..1432774 + 1758 WP_025811589.1 gamma-glutamyltransferase -
PWG69_RS07220 (PWG69_07220) 1432909..1433553 + 645 WP_023856740.1 YesL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-57)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29421.87 Da        Isoelectric Point: 4.6015

>T273398 WP_023856735.1 NZ_CP118744:c1428946-1428200 [Bacillus paralicheniformis]
MLLFYQFLVWLIVLALALYVAAVWRFEKKLTEKTVAIRKTWYLLYVIGAVIYWTHDPQSIFTNPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSSELATDTRMLLEENNDLLHTYQNRLKTFQYLLKNEPIHIYYGNIEAYAEGIEKLIKRFAEKMNISAAL
CEYNSEESKDHLLEHMENRFDVQEKLERKDVYYEENGKMVLIPFSIHDFDYVMKLTSEDLVTEFDYLLFTSLTSIYDLLL
PNEEDGDD

Download         Length: 747 bp

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6897.99 Da        Isoelectric Point: 10.8356

>AT273398 WP_023856734.1 NZ_CP118744:c1428200-1428027 [Bacillus paralicheniformis]
MEPAFQQDHESAKKRLAFKMFKKQSKTNIAKYEVSPHTERIFRQNERLIGEYKRKKA

Download         Length: 174 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7TYV7

Antitoxin

Source ID Structure
AlphaFold DB A0A6I7TM13

References