Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 197348..197984 Replicon chromosome
Accession NZ_CP118718
Organism Priestia aryabhattai strain G5MAi6

Toxin (Protein)


Gene name mazF Uniprot ID D5DWT4
Locus tag PWO00_RS01120 Protein ID WP_013055004.1
Coordinates 197634..197984 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID D5DWT3
Locus tag PWO00_RS01115 Protein ID WP_013055003.1
Coordinates 197348..197629 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWO00_RS01090 (PWO00_01090) 192714..193685 + 972 WP_074683554.1 UV DNA damage repair endonuclease UvsE -
PWO00_RS01095 (PWO00_01095) 193694..194296 - 603 WP_275036680.1 rhomboid family intramembrane serine protease -
PWO00_RS01100 (PWO00_01100) 194361..194726 + 366 WP_028411881.1 holo-ACP synthase -
PWO00_RS01105 (PWO00_01105) 194785..195843 + 1059 WP_221816542.1 outer membrane lipoprotein carrier protein LolA -
PWO00_RS01110 (PWO00_01110) 195957..197147 + 1191 WP_275036681.1 alanine racemase -
PWO00_RS01115 (PWO00_01115) 197348..197629 + 282 WP_013055003.1 hypothetical protein Antitoxin
PWO00_RS01120 (PWO00_01120) 197634..197984 + 351 WP_013055004.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
PWO00_RS01125 (PWO00_01125) 198142..198978 + 837 WP_221816540.1 RsbT co-antagonist protein RsbRA -
PWO00_RS01130 (PWO00_01130) 198981..199337 + 357 WP_013055006.1 STAS domain-containing protein -
PWO00_RS01135 (PWO00_01135) 199341..199742 + 402 WP_013055007.1 anti-sigma regulatory factor -
PWO00_RS01140 (PWO00_01140) 199756..200766 + 1011 WP_045295109.1 PP2C family protein-serine/threonine phosphatase -
PWO00_RS01145 (PWO00_01145) 200826..201158 + 333 WP_013055009.1 anti-sigma factor antagonist -
PWO00_RS01150 (PWO00_01150) 201155..201640 + 486 WP_025753516.1 anti-sigma B factor RsbW -
PWO00_RS01155 (PWO00_01155) 201606..202400 + 795 WP_275036682.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12991.96 Da        Isoelectric Point: 4.8781

>T273384 WP_013055004.1 NZ_CP118718:197634-197984 [Priestia aryabhattai]
MVVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVDEALQISVGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10691.22 Da        Isoelectric Point: 8.5339

>AT273384 WP_013055003.1 NZ_CP118718:197348-197629 [Priestia aryabhattai]
VSEASATTEILVRLPKNLVSELDLMVKQENGNRSDFIHQATKLYLRERKKRHIRESMRRGYMEMAKINLNIASEAFLAEY
EADHTVDRLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0B6AMB9

References