Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 587505..589219 Replicon chromosome
Accession NZ_CP118699
Organism Aeromonas hydrophila strain K522

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag PWO56_RS02880 Protein ID WP_270697464.1
Coordinates 587505..588158 (+) Length 218 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag PWO56_RS02885 Protein ID WP_270697465.1
Coordinates 588155..589219 (+) Length 355 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWO56_RS02860 (PWO56_02860) 582536..582724 + 189 WP_021138010.1 DUF3283 family protein -
PWO56_RS02865 (PWO56_02865) 582871..583317 + 447 WP_043852095.1 hypothetical protein -
PWO56_RS02870 (PWO56_02870) 583504..585951 + 2448 WP_113995997.1 type I restriction-modification system subunit M -
PWO56_RS02875 (PWO56_02875) 585951..587228 + 1278 WP_113995996.1 restriction endonuclease subunit S -
PWO56_RS02880 (PWO56_02880) 587505..588158 + 654 WP_270697464.1 DUF4433 domain-containing protein Toxin
PWO56_RS02885 (PWO56_02885) 588155..589219 + 1065 WP_270697465.1 macro domain-containing protein Antitoxin
PWO56_RS02890 (PWO56_02890) 589294..592425 + 3132 WP_270697466.1 HsdR family type I site-specific deoxyribonuclease -
PWO56_RS02895 (PWO56_02895) 592425..593138 + 714 WP_005331303.1 SprT family zinc-dependent metalloprotease -
PWO56_RS02900 (PWO56_02900) 593157..594095 - 939 WP_171269279.1 restriction endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(17-216)

Antitoxin

Macro domain

(18-131)


Sequences

Toxin        


Download         Length: 218 a.a.        Molecular weight: 25414.08 Da        Isoelectric Point: 7.2463

>T273376 WP_270697464.1 NZ_CP118699:587505-588158 [Aeromonas hydrophila]
MAYDYSQSLNPQKALIFRIVHRDNLEWILTHGLWAGNGQQQNPHWVHIGLPELIAKRARHPVPLVPYGVLNDYVPFYFTP
FSPMLSNIHSGRGVPRRENDEILILVSSLHRMAELGLPFVFTDSHAYYQWANFYVDLGDLGRIDWPLLQRRDFKRDAEDL
SKLERYQAEALIHQHCPIEALLGVVCYNEEIKNRVEQCMNRVGVARPVYVRDGWYFR

Download         Length: 654 bp

Antitoxin


Download         Length: 355 a.a.        Molecular weight: 39660.86 Da        Isoelectric Point: 6.8633

>AT273376 WP_270697465.1 NZ_CP118699:588155-589219 [Aeromonas hydrophila]
MIRYTTGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPANMRAYAEACKLGDVVTGKMFITQTGELLGPRWIVNFPTK
QHWRNPAQMAWIQDGLQDLRAWLQAQQVSSIAIPPLGAGNGGLPWPEVKQAIETALGDLDIDILLYEPSRQYQNVAKRGG
VVELTPARALIAELVRRYWFLGMECSLLEIQKLAWFLARVIGRNSLGDPLQLQFKAHRYGPYANNLTHLLNAMDGSYLQS
DKRIPDSKPFDVIWFNEAKKQELAVYLQTEAKAFLPILEQTTALIDGFESPYGMELLATVDWLIAEEGCAPTLSALREGL
HRWPAGTPWGERKARLFDDRSLQIALTRLQQGLV

Download         Length: 1065 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References