Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2505134..2505769 Replicon chromosome
Accession NZ_CP118675
Organism Komagataeibacter nataicola strain DS12

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LV564_RS12620 Protein ID WP_275881235.1
Coordinates 2505134..2505544 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G2I1D7
Locus tag LV564_RS12625 Protein ID WP_010511771.1
Coordinates 2505545..2505769 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV564_RS12605 (LV564_12615) 2501019..2503928 - 2910 WP_075596346.1 AAA family ATPase -
LV564_RS12610 (LV564_12620) 2504092..2504358 + 267 WP_239016082.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
LV564_RS12615 (LV564_12625) 2504339..2504728 + 390 WP_075596344.1 type II toxin-antitoxin system VapC family toxin -
LV564_RS12620 (LV564_12630) 2505134..2505544 - 411 WP_275881235.1 type II toxin-antitoxin system VapC family toxin Toxin
LV564_RS12625 (LV564_12635) 2505545..2505769 - 225 WP_010511771.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LV564_RS12630 (LV564_12640) 2505949..2506374 + 426 WP_275881236.1 hypothetical protein -
LV564_RS12635 (LV564_12645) 2506401..2506658 - 258 WP_275881237.1 hypothetical protein -
LV564_RS12640 (LV564_12650) 2506692..2507627 - 936 WP_275881238.1 recombinase family protein -
LV564_RS12645 (LV564_12655) 2507576..2507944 - 369 WP_275881239.1 recombinase family protein -
LV564_RS12650 (LV564_12660) 2508418..2510298 + 1881 WP_275881240.1 hypothetical protein -
LV564_RS12655 (LV564_12665) 2510385..2510705 + 321 WP_275881241.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(9-55)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15465.65 Da        Isoelectric Point: 6.7161

>T273369 WP_275881235.1 NZ_CP118675:c2505544-2505134 [Komagataeibacter nataicola]
MLRYLLDTNLCIRVLRDRPQGLRPRFNSCAEELSLSDVVLYELLYGAERSSDPVRTRREVEHFAARLAVLPFDSEAAAHT
ADIRAALERNGRIIGPYDLMIAGHARSRGLIVVTGNLREFQRVEGLRTEDWLTDTV

Download         Length: 411 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8217.39 Da        Isoelectric Point: 4.9816

>AT273369 WP_010511771.1 NZ_CP118675:c2505769-2505545 [Komagataeibacter nataicola]
MLTRTTLFLSNRSQAVRLPKMVAFGEQVRDVVIVSEGSRRIIAPADAAWDDFFAAPGVDLGERNQPAMQEREAL

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A094ZE42

References