Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 7129..7760 Replicon chromosome
Accession NZ_CP118675
Organism Komagataeibacter nataicola strain DS12

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LV564_RS01200 Protein ID WP_182999298.1
Coordinates 7368..7760 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LV564_RS01195 Protein ID WP_275881357.1
Coordinates 7129..7371 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV564_RS01185 (LV564_01190) 2749..4290 - 1542 WP_275881355.1 DNA cytosine methyltransferase -
LV564_RS01190 (LV564_01195) 4899..6899 - 2001 WP_275881356.1 DNA topoisomerase III -
LV564_RS01195 (LV564_01200) 7129..7371 + 243 WP_275881357.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LV564_RS01200 (LV564_01205) 7368..7760 + 393 WP_182999298.1 type II toxin-antitoxin system VapC family toxin Toxin
LV564_RS01205 (LV564_01210) 7820..8203 - 384 WP_275881358.1 single-stranded DNA-binding protein -
LV564_RS01210 (LV564_01215) 8200..9207 - 1008 WP_275881359.1 site-specific DNA-methyltransferase -
LV564_RS01215 (LV564_01220) 9204..9713 - 510 WP_275881360.1 DUF3158 family protein -
LV564_RS01220 (LV564_01225) 9854..10528 - 675 Protein_9 TIGR03761 family integrating conjugative element protein -
LV564_RS01225 (LV564_01230) 11199..11576 + 378 WP_182999301.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14488.54 Da        Isoelectric Point: 6.9894

>T273367 WP_182999298.1 NZ_CP118675:7368-7760 [Komagataeibacter nataicola]
VKYLLDSNAVIALLKGHPGFLSRLHQHTPSDFGLSAIVTHELYYGAYKGSRRAENLARVDALRFAVLEFDREDSLRAGEL
RALLAQAGTPIGPLDVLIAGQAWARGLILITHNVREFQRVAQIQVEDWQD

Download         Length: 393 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9325.49 Da        Isoelectric Point: 4.5098

>AT273367 WP_275881357.1 NZ_CP118675:7129-7371 [Komagataeibacter nataicola]
MDTAKIFWSGRSQAVRLPKEFRLDADEVRIRRHGASIILEPVAQDWAWLKEVTGPVDEEFERAVTEPVAQQDRPELDFFQ

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References