273362

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5176771..5177379 Replicon chromosome
Accession NZ_CP118641
Organism Pseudomonas aeruginosa strain P23

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag PUL49_RS24120 Protein ID WP_003114156.1
Coordinates 5176771..5177118 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag PUL49_RS24125 Protein ID WP_003114155.1
Coordinates 5177128..5177379 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUL49_RS24090 (PUL49_24075) 5172190..5172402 + 213 WP_003098360.1 cysteine-rich CWC family protein -
PUL49_RS24095 (PUL49_24080) 5172402..5173094 + 693 WP_003098362.1 16S rRNA pseudouridine(516) synthase -
PUL49_RS24100 (PUL49_24085) 5173230..5174273 + 1044 WP_003098363.1 L,D-transpeptidase -
PUL49_RS24105 (PUL49_24090) 5174353..5175090 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
PUL49_RS24110 (PUL49_24095) 5175542..5176444 + 903 WP_003085447.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
PUL49_RS24120 (PUL49_24105) 5176771..5177118 - 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PUL49_RS24125 (PUL49_24110) 5177128..5177379 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PUL49_RS24130 (PUL49_24115) 5177593..5178576 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
PUL49_RS24135 (PUL49_24120) 5178576..5179868 - 1293 WP_003115206.1 hypothetical protein -
PUL49_RS24140 (PUL49_24125) 5180098..5181372 - 1275 WP_281004908.1 zonular occludens toxin family protein -
PUL49_RS24145 (PUL49_24130) 5181376..5181732 - 357 WP_003114150.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 5176771..5201090 24319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T273362 WP_003114156.1 NZ_CP118641:c5177118-5176771 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT273362 WP_003114155.1 NZ_CP118641:c5177379-5177128 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References