Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4792760..4794018 Replicon chromosome
Accession NZ_CP118641
Organism Pseudomonas aeruginosa strain P23

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag PUL49_RS22340 Protein ID WP_003086331.1
Coordinates 4792760..4793515 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PUL49_RS22345 Protein ID WP_003086329.1
Coordinates 4793650..4794018 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUL49_RS22330 (PUL49_22315) 4787931..4790474 + 2544 WP_273658609.1 acyl-homoserine-lactone acylase QuiP -
PUL49_RS22335 (PUL49_22320) 4790629..4791990 - 1362 WP_003081943.1 DNA recombination protein RmuC -
PUL49_RS22340 (PUL49_22325) 4792760..4793515 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
PUL49_RS22345 (PUL49_22330) 4793650..4794018 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PUL49_RS22350 (PUL49_22335) 4794091..4795377 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
PUL49_RS22355 (PUL49_22340) 4795433..4796926 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
PUL49_RS22360 (PUL49_22345) 4797101..4797577 + 477 WP_003140638.1 hypothetical protein -
PUL49_RS22365 (PUL49_22350) 4797580..4797855 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T273361 WP_003086331.1 NZ_CP118641:c4793515-4792760 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT273361 WP_003086329.1 NZ_CP118641:c4794018-4793650 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References