Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3793119..3794340 Replicon chromosome
Accession NZ_CP118641
Organism Pseudomonas aeruginosa strain P23

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag PUL49_RS17675 Protein ID WP_003102740.1
Coordinates 3793762..3794340 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PUL49_RS17670 Protein ID WP_003088112.1
Coordinates 3793119..3793673 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUL49_RS17645 (PUL49_17630) 3788687..3789238 + 552 WP_003102727.1 XRE family transcriptional regulator -
PUL49_RS17650 (PUL49_17635) 3789235..3789633 - 399 WP_023089053.1 NADH-quinone oxidoreductase subunit A -
PUL49_RS17655 (PUL49_17640) 3789646..3789969 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PUL49_RS17660 (PUL49_17645) 3790300..3790761 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PUL49_RS17665 (PUL49_17650) 3790766..3792961 + 2196 WP_043096806.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PUL49_RS17670 (PUL49_17655) 3793119..3793673 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PUL49_RS17675 (PUL49_17660) 3793762..3794340 + 579 WP_003102740.1 HD domain-containing protein Toxin
PUL49_RS17680 (PUL49_17665) 3794449..3795636 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PUL49_RS17685 (PUL49_17670) 3795626..3797797 - 2172 WP_273658821.1 type I secretion system permease/ATPase -
PUL49_RS17690 (PUL49_17675) 3797787..3799064 - 1278 WP_003122808.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T273360 WP_003102740.1 NZ_CP118641:3793762-3794340 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT273360 WP_003088112.1 NZ_CP118641:3793119-3793673 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References