Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | slvAT/RES(toxin) |
| Location | 275737..276653 | Replicon | plasmid pP9Me1 |
| Accession | NZ_CP118639 | ||
| Organism | Pseudomonas aeruginosa strain P9 | ||
Toxin (Protein)
| Gene name | slvT | Uniprot ID | A0A2L1KI32 |
| Locus tag | PUN20_RS32120 | Protein ID | WP_019437783.1 |
| Coordinates | 275737..276261 (-) | Length | 175 a.a. |
Antitoxin (Protein)
| Gene name | slvA | Uniprot ID | A0A2L1KH13 |
| Locus tag | PUN20_RS32125 | Protein ID | WP_019437782.1 |
| Coordinates | 276258..276653 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PUN20_RS32100 (PUN20_32090) | 271003..272148 | + | 1146 | WP_021263240.1 | glycerate kinase | - |
| PUN20_RS32105 (PUN20_32095) | 272623..272814 | - | 192 | WP_019437785.1 | hypothetical protein | - |
| PUN20_RS32110 (PUN20_32100) | 273189..274244 | + | 1056 | WP_109392701.1 | prepilin-type N-terminal cleavage/methylation domain-containing protein | - |
| PUN20_RS32115 (PUN20_32105) | 274441..275691 | + | 1251 | WP_019437784.1 | TerD family protein | - |
| PUN20_RS32120 (PUN20_32110) | 275737..276261 | - | 525 | WP_019437783.1 | RES family NAD+ phosphorylase | Toxin |
| PUN20_RS32125 (PUN20_32115) | 276258..276653 | - | 396 | WP_019437782.1 | hypothetical protein | Antitoxin |
| PUN20_RS32130 (PUN20_32120) | 277237..279120 | - | 1884 | WP_223819158.1 | helicase | - |
| PUN20_RS32135 (PUN20_32125) | 279320..279574 | + | 255 | WP_021263738.1 | hypothetical protein | - |
| PUN20_RS32140 (PUN20_32130) | 280468..280992 | + | 525 | WP_010794447.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | sul1 / qacE / ant(3'')-Ia / blaOXA-520 / cmlA1 | - | 1..422938 | 422938 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 175 a.a. Molecular weight: 19052.57 Da Isoelectric Point: 4.5535
>T273357 WP_019437783.1 NZ_CP118639:c276261-275737 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQASAFLPPGLLISYSLSLDRVI
DFTGGYNDTWAPIWQDFFCDWRKIRFNDGVEPPSWIIGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQASAFLPPGLLISYSLSLDRVI
DFTGGYNDTWAPIWQDFFCDWRKIRFNDGVEPPSWIIGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP
Download Length: 525 bp
Antitoxin
Download Length: 132 a.a. Molecular weight: 14753.87 Da Isoelectric Point: 7.2048
>AT273357 WP_019437782.1 NZ_CP118639:c276653-276258 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFGYKTAEEVVSEGKTEQLIAFLQSWEAGAQG
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFGYKTAEEVVSEGKTEQLIAFLQSWEAGAQG
Download Length: 396 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2L1KI32 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2L1KH13 |