273355

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4926133..4926741 Replicon chromosome
Accession NZ_CP118638
Organism Pseudomonas aeruginosa strain P9

Toxin (Protein)


Gene name PfiT Uniprot ID A0A1B1XUZ2
Locus tag PUN20_RS23080 Protein ID WP_003123043.1
Coordinates 4926133..4926480 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag PUN20_RS23085 Protein ID WP_003114155.1
Coordinates 4926490..4926741 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUN20_RS23050 (PUN20_23035) 4921552..4921764 + 213 WP_023082749.1 cysteine-rich CWC family protein -
PUN20_RS23055 (PUN20_23040) 4921764..4922456 + 693 WP_016851968.1 16S rRNA pseudouridine(516) synthase -
PUN20_RS23060 (PUN20_23045) 4922592..4923635 + 1044 WP_003134392.1 L,D-transpeptidase -
PUN20_RS23065 (PUN20_23050) 4923715..4924452 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
PUN20_RS23070 (PUN20_23055) 4924904..4925806 + 903 WP_014603238.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
PUN20_RS23080 (PUN20_23065) 4926133..4926480 - 348 WP_003123043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PUN20_RS23085 (PUN20_23070) 4926490..4926741 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PUN20_RS23090 (PUN20_23075) 4926954..4927936 - 983 Protein_4568 tyrosine-type recombinase/integrase -
PUN20_RS23095 (PUN20_23080) 4927936..4929228 - 1293 WP_023090049.1 hypothetical protein -
PUN20_RS23100 (PUN20_23085) 4929866..4930255 - 390 WP_034053350.1 hypothetical protein -
PUN20_RS23105 (PUN20_23090) 4930248..4930463 - 216 WP_023090052.1 hypothetical protein -
PUN20_RS23110 (PUN20_23095) 4930486..4930701 - 216 WP_023090053.1 hypothetical protein -
PUN20_RS23115 (PUN20_23100) 4930853..4931098 + 246 WP_228380994.1 DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4925983..4935958 9975


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12990.74 Da        Isoelectric Point: 4.4212

>T273355 WP_003123043.1 NZ_CP118638:c4926480-4926133 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT273355 WP_003114155.1 NZ_CP118638:c4926741-4926490 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1XUZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References