Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3611877..3613098 Replicon chromosome
Accession NZ_CP118638
Organism Pseudomonas aeruginosa strain P9

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag PUN20_RS16710 Protein ID WP_003102740.1
Coordinates 3612520..3613098 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PUN20_RS16705 Protein ID WP_003088112.1
Coordinates 3611877..3612431 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUN20_RS16680 (PUN20_16665) 3607445..3607996 + 552 WP_003102727.1 XRE family transcriptional regulator -
PUN20_RS16685 (PUN20_16670) 3607993..3608391 - 399 WP_003102731.1 NADH-quinone oxidoreductase subunit A -
PUN20_RS16690 (PUN20_16675) 3608404..3608727 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PUN20_RS16695 (PUN20_16680) 3609058..3609519 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PUN20_RS16700 (PUN20_16685) 3609524..3611719 + 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PUN20_RS16705 (PUN20_16690) 3611877..3612431 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PUN20_RS16710 (PUN20_16695) 3612520..3613098 + 579 WP_003102740.1 HD domain-containing protein Toxin
PUN20_RS16715 (PUN20_16700) 3613207..3614394 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PUN20_RS16720 (PUN20_16705) 3614384..3616555 - 2172 WP_088412823.1 type I secretion system permease/ATPase -
PUN20_RS16725 (PUN20_16710) 3616545..3617822 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T273353 WP_003102740.1 NZ_CP118638:3612520-3613098 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT273353 WP_003088112.1 NZ_CP118638:3611877-3612431 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References