Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1838024..1839532 Replicon chromosome
Accession NZ_CP118638
Organism Pseudomonas aeruginosa strain P9

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag PUN20_RS08545 Protein ID WP_003119682.1
Coordinates 1838024..1838611 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag PUN20_RS08550 Protein ID WP_012613852.1
Coordinates 1838678..1839532 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUN20_RS08540 (PUN20_08535) 1834279..1837758 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
PUN20_RS08545 (PUN20_08540) 1838024..1838611 + 588 WP_003119682.1 GNAT family protein Toxin
PUN20_RS08550 (PUN20_08545) 1838678..1839532 + 855 WP_012613852.1 AraC family transcriptional regulator Antitoxin
PUN20_RS08555 (PUN20_08550) 1839629..1841794 + 2166 WP_003115567.1 TonB-dependent receptor family protein -
PUN20_RS08560 (PUN20_08555) 1841969..1843843 + 1875 WP_003117607.1 MFS transporter -
PUN20_RS08565 (PUN20_08560) 1843904..1844113 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T273352 WP_003119682.1 NZ_CP118638:1838024-1838611 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31959.27 Da        Isoelectric Point: 7.3276

>AT273352 WP_012613852.1 NZ_CP118638:1838678-1839532 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLPVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References